Mouse Anti-BAG4 Recombinant Antibody (2G9) (CBMAB-A0701-LY)

Name: Mouse Anti-BAG4 Recombinant Antibody (2G9)
SKU: CBMAB-A0701-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2G9

Application

WB, ELISA

Immunogen

BAG4 (AAH38505, 1 a.a. ~ 457 a.a) full-length recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

BCL2-associated athanogene 4

Introduction

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. [provided by RefSeq]

Entrez Gene ID

9530

UniProt ID

O95429

Alternative Names

BAG-4; SODD

Function

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity).
Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.

Biological Process

Cellular response to epidermal growth factor stimulus Source: Ensembl
Cellular response to tumor necrosis factor Source: UniProtKB
Negative regulation of apoptotic process Source: ProtInc
Negative regulation of mRNA modification Source: Ensembl
Negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Source: Ensembl
Negative regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
Positive regulation of actin filament polymerization Source: Ensembl
Positive regulation of cell adhesion Source: Ensembl
Positive regulation of fibroblast migration Source: Ensembl
Positive regulation of peptidyl-serine phosphorylation Source: Ensembl
Positive regulation of protein kinase B signaling Source: Ensembl
Positive regulation of stress fiber assembly Source: Ensembl
Protein folding Source: ProtInc
Protein localization to plasma membrane Source: Ensembl
Protein stabilization Source: GO_Central
Regulation of cellular response to heat Source: Reactome
Ruffle assembly Source: Ensembl
Tumor necrosis factor-mediated signaling pathway Source: Reactome

Cellular Location

Cytoplasm

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

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Rabbit Anti-BAG4 Recombinant Antibody (CBXS-1495) (CAT#: CBMAB-S4348-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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