BDKRB1

Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Full Name

Bradykinin Receptor B1

Function

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
GO - Molecular functioni

Biological Process

Cell migration Source: Ensembl
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: Ensembl
Negative regulation of blood pressure Source: Ensembl
Negative regulation of cell growth Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Positive regulation of leukocyte migration Source: Ensembl
Positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: InterPro
Sensory perception of pain Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-40 aa
Helical: 41-64 aa
Cytoplasmic: 65-73 aa
Helical: 74-98 aa
Extracellular: 99-111 aa
Helical: 112-133 aa
Cytoplasmic: 134-155 aa
Helical: 156-178 aa
Extracellular: 179-199 aa
Helical: 200-226 aa
Cytoplasmic: 227-247 aa
Helical: 248-272 aa
Extracellular: 273-291 aa
Helical: 292-314 aa
Cytoplasmic: 315-353 aa