Sign in or Register   Sign in or Register
  |  

Mouse Anti-BDKRB1 Recombinant Antibody (CBYY-2018) (CBMAB-2367-YY)

This product is mouse antibody that recognizes BDKRB1. The antibody CBYY-2018 can be used for immunoassay techniques such as: ELISA, WB
See all BDKRB1 antibodies
Published Data
Mouse Anti-BDKRB1 Recombinant Antibody (CBYY-2018) (CBMAB-2367-YY) in WB
B1R protein levels. ...View More
Song, J., Du, J., Tan, X., Wu, Z., Yuan, J., & Cong, B. (2021). Dexmedetomidine protects the heart against ischemia reperfusion injury via regulation of the bradykinin receptors. European Journal of Pharmacology, 911, 174493.
Mouse Anti-BDKRB1 Recombinant Antibody (CBYY-2018) (CBMAB-2367-YY) in WB
B1R protein levels. ...View More
Song, J., Du, J., Tan, X., Wu, Z., Yuan, J., & Cong, B. (2021). Dexmedetomidine protects the heart against ischemia reperfusion injury via regulation of the bradykinin receptors. European Journal of Pharmacology, 911, 174493.
Mouse Anti-BDKRB1 Recombinant Antibody (CBYY-2018) (CBMAB-2367-YY) in WB
The protein expression of BK receptor type was analyzed by western blot in mesenteric artery homogenates derived from age-matched SHRs and Wistar rats. ...View More
Khaddaj Mallat, R., Mathew John, C., Mishra, R. C., Kendrick, D. J., & Braun, A. P. (2019). Pharmacological Targeting of KCa Channels to Improve Endothelial Function in the Spontaneously Hypertensive Rat. International Journal of Molecular Sciences, 20(14), 3481.
Mouse Anti-BDKRB1 Recombinant Antibody (CBYY-2018) (CBMAB-2367-YY) in WB
High glucose inhibits the mRNA and protein expression of bradykinin receptors and EphB4/EphrinB2. The mRNA and protein expression levels of (A and B) bradykinin receptors and (C and D) EphB4/EphrinB2 were measured by RT-PCR and western blot analysis, respectively. ...View More
Wu, M., Ai, W., Chen, L., Zhao, S., & Liu, E. (2016). Bradykinin receptors and EphB2/EphrinB2 pathway in response to high glucose-induced osteoblast dysfunction and hyperglycemia-induced bone deterioration in mice Corrigendum in/10.3892/ijmm. 2019.4091. International Journal of Molecular Medicine, 37(3), 565-574.
Mouse Anti-BDKRB1 Recombinant Antibody (CBYY-2018) (CBMAB-2367-YY) in WB
Hyperglycemia inhibits the mRNA and protein expression of bradykinin receptors and EphB4/EphrinB2 in tibias of mice. The (A) mRNA and (B) protein expression of bradykinin receptors and EphB4/EphrinB2 were measured by RT-PCR and western blot analysis, respectively. Values are expressed as the means ± SEM, n=6-8 in each group. *P<0.05 vs. control group. ...View More
Wu, M., Ai, W., Chen, L., Zhao, S., & Liu, E. (2016). Bradykinin receptors and EphB2/EphrinB2 pathway in response to high glucose-induced osteoblast dysfunction and hyperglycemia-induced bone deterioration in mice Corrigendum in/10.3892/ijmm. 2019.4091. International Journal of Molecular Medicine, 37(3), 565-574.

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-2018
Antibody Isotype
IgG2a, κ
Application
ELISA, WB, IP

Basic Information

Immunogen
Recombinant protein mapping within amino acids 1-353, representing full length bradykinin B1 R of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Bradykinin Receptor B1
Introduction
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforMouse have been found for this gene.
Entrez Gene ID
623
UniProt ID
P46663
Alternative Names
Bradykinin Receptor B1; BK-1 Receptor; BRADYB1; B1R; B1 Bradykinin Receptor; Bradykinin B1 Receptor; Bradykinin Receptor B2;
Function
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
GO - Molecular functioni
Biological Process
Cell migration Source: Ensembl
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: Ensembl
Negative regulation of blood pressure Source: Ensembl
Negative regulation of cell growth Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Positive regulation of leukocyte migration Source: Ensembl
Positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: InterPro
Sensory perception of pain Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-40 aa
Helical: 41-64 aa
Cytoplasmic: 65-73 aa
Helical: 74-98 aa
Extracellular: 99-111 aa
Helical: 112-133 aa
Cytoplasmic: 134-155 aa
Helical: 156-178 aa
Extracellular: 179-199 aa
Helical: 200-226 aa
Cytoplasmic: 227-247 aa
Helical: 248-272 aa
Extracellular: 273-291 aa
Helical: 292-314 aa
Cytoplasmic: 315-353 aa
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-BDKRB1 Recombinant Antibody (CBYY-2018)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare