C1R

C1R (Complement C1r) is a Protein Coding gene. Diseases associated with C1R include Ehlers-Danlos Syndrome, Periodontal Type, 1 and Periodontal Ehlers-Danlos Syndrome. Among its related pathways are Creation of C4 and C2 activators and Complement and coagulation cascades.
Gene Ontology (GO) annotations related to this gene include calcium ion binding and serine-type peptidase activity. An important paralog of this gene is MASP2.
Full Name
Complement C1r
Function
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
Biological Process
Complement activation Source: Reactome
Complement activation, classical pathway Source: Reactome
Immune response Source: ProtInc
Innate immune response Source: UniProtKB-KW
Regulation of complement activation Source: Reactome
Zymogen activation Source: CAFA
Cellular Location
Secreted
Involvement in disease
Ehlers-Danlos syndrome, periodontal type, 1 (EDSPD1): A form of Ehlers-Danlos syndrome, a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDSPD1 is characterized by the association of typical features of Ehlers-Danlos syndrome with gingival recession and severe early-onset periodontal disease, leading to premature loss of permanent teeth. EDSPD1 inheritance is autosomal dominant.
PTM
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
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Anti-C1R antibodies

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Mouse Anti-C1R Recombinant Antibody (CBFYC-0609) (CBMAB-C0663-FY)

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Target: C1R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0609
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-C1R Recombinant Antibody (CBFYC-0608) (CBMAB-C0662-FY)

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Target: C1R
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog
Clone: CBFYC-0608
Application*: WB
Datasheet SDS

Mouse Anti-C1R Recombinant Antibody (CBFYC-0607) (CBMAB-C0661-FY)

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Target: C1R
Host: Mouse
Antibody Isotype: IgG2b, ĸ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0607
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-C1R Recombinant Antibody (5A11) (CBMAB-C7257-LY)

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Target: C1R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5A11
Application*: FC, WB
Datasheet SDS

Mouse Anti-C1R Recombinant Antibody (269104) (CBMAB-C4501-LY)

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Target: C1R
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 269104
Application*: IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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