CaMKK1

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
Full Name
Calcium/Calmodulin Dependent Protein Kinase Kinase 1
Function
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
Biological Process
Chemical synaptic transmission Source: Reactome
Intracellular signal transduction Source: GO_Central
Positive regulation of protein kinase activity Source: GO_Central
Cellular Location
Cytoplasm; Nucleus
PTM
Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity).
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Anti-CaMKK1 antibodies

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Mouse Anti-CAMKK1 Recombinant Antibody (CBXC-2003) (CBMAB-C5528-CQ)

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Target: CAMKK1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-2003
Application*: E, WB
Datasheet SDS

Mouse Anti-CAMKK1 Recombinant Antibody (CBFYC-0777) (CBMAB-C0832-FY)

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Target: CAMKK1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse, Rat
Clone: CBFYC-0777
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-CAMKK1 Recombinant Antibody (4B4) (CBMAB-C6654-LY)

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Target: CAMKK1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B4
Application*: E, WB
Datasheet SDS

Mouse Anti-CaMKK1 Recombinant Antibody (4A11) (CBMAB-C6547-LY)

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Target: CAMKK1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4A11
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-CaMKK1 Recombinant Antibody (1F6) (CBMAB-C0523-LY)

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Target: CAMKK1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F6
Application*: E, IH, WB
Datasheet SDS

CAMKK1 Matched Antibody Pair (176) (APMAB-176LY)

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Target: CAMKK1
Specificity: Human
Datasheet SDS

Mouse Anti-CAMKK1 Recombinant Antibody (CBYY-C0918) (CBMAB-C2355-YY)

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Target: CAMKK1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C0918
Application*: E, WB
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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