CAMKK1 Matched Antibody Pair (176) (APMAB-176LY)

This antibody pair set can be used for detecting and quantifying protein level of human CAMKK1.
See all CAMKK1 antibodies

Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-CAMKK1 polyclonal antibody, 100 ug

Detection Antibody

Anti-CAMKK1 Mouse polyclonal antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]

Alternative Names

Calcium/Calmodulin Dependent Protein Kinase Kinase 1; Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha; Calcium/Calmodulin-Dependent Protein Kinase Kinase 1, Alpha; CaM-Kinase Kinase Alpha; CaM-Kinase IV Kinase; CaM-Kinase Kinase 1; CaM-KK Alpha; CaM-KK 1;

Entrez Gene ID

84254

UniProt ID

Q8N5S9

References

Beghi, S., Cavaliere, F., Manfredini, M., Ferrarese, S., Corazzari, C., Beghi, C., & Buschini, A. (2021). Polymorphism rs7214723 in CAMKK1: a new genetic variant associated with cardiovascular diseases. Bioscience Reports, 41(7), BSR20210326.

Mikulů, M. (2020). Studium struktury komplexů proteinu 14-3-3 s CaMKK1 a CaMKK1: Ca2+/CaM.

Prajisha, J., Biswal, J., & Jeyakanthan, J. (2020). Discovery of potent Camkk1 kinase inhibitors through e-pharmacophore and molecular screening approaches. Journal of Biomolecular Structure and Dynamics, 1-17.

AdS, S., Couñago, R. M., Godoi, P. H. C., Massirer, K. B., Gileadi, O., & Elkins, J. M. (2018). Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors.

da Silva Santiago, A., Couñago, R. M., Ramos, P. Z., Godoi, P. H., Massirer, K. B., Gileadi, O., & Elkins, J. M. (2018). Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors. Scientific reports, 8(1), 1-10.

Dong, F., Patnaik, S., Duan, Z. H., Kiedrowski, M., Penn, M. S., & Mayorga, M. E. (2017). A novel role for CAMKK1 in the regulation of the mesenchymal stem cell secretome. Stem cells translational medicine, 6(9), 1759-1766.

Wang, J., Lan, X., Jiang, S., Ma, Y., Zhang, S., Li, Y., ... & Lan, H. (2017). CaMKK1 from Chenopodium album positively regulates salt and drought tolerance in transgenic tobacco. Plant Cell, Tissue and Organ Culture (PCTOC), 130(1), 209-225.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-CaMKK1 Recombinant Antibody (4A11)

Mouse Anti-CAMKK1 Recombinant Antibody (4B4)

Mouse Anti-CAMKK1 Recombinant Antibody (CBXC-2003)

Mouse Anti-CAMKK1 Recombinant Antibody (CBYY-C0918)

Mouse Anti-CAMKK1 (AA 1-520) Recombinant Antibody (CBFYC-0777)

Mouse Anti-CAMKK1 Recombinant Antibody (CBLC075-LY)

Mouse Anti-CAMKK1 Recombinant Antibody (6/CaM Kinase Kinase)

Mouse Anti-CaMKK1 Recombinant Antibody (1F6)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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