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Mouse Anti-CAMKK1 Recombinant Antibody (CBXC-2003) (CBMAB-C5528-CQ)

This product is a mouse antibody that recognizes CAMKK1. The antibody CBXC-2003 can be used for immunoassay techniques such as: ELISA, WB, IHC.
See all CAMKK1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2003
Antibody Isotype
IgG1, κ
Application
ELISA, WB, IHC

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Calcium/Calmodulin Dependent Protein Kinase Kinase 1
Introduction
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases.
Entrez Gene ID
UniProt ID
Alternative Names
Calcium/Calmodulin Dependent Protein Kinase Kinase 1; Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha; Calcium/Calmodulin-Dependent Protein Kinase Kinase 1, Alpha; CaM-Kinase Kinase Alpha; CaM-Kinase IV Kinase; CaM-Kinase Kinase 1; CaM-KK Alpha; CaM-KK 1;
Function
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
Biological Process
Chemical synaptic transmission Source: Reactome
Intracellular signal transduction Source: GO_Central
Positive regulation of protein kinase activity Source: GO_Central
Cellular Location
Cytoplasm; Nucleus
PTM
Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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