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Mouse Anti-CAMKK1 Recombinant Antibody (CBXC-2003) (CBMAB-C5528-CQ)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBXC-2003
Application
ELISA, WB
Immunogen
CAMKK1 (AAH31647, 1 a.a. ~ 520 a.a) full-length recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Calcium/Calmodulin Dependent Protein Kinase Kinase 1
Introduction
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases.
Entrez Gene ID
84254
UniProt ID
Q8N5S9
Alternative Names
Calcium/Calmodulin Dependent Protein Kinase Kinase 1; Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha; Calcium/Calmodulin-Dependent Protein Kinase Kinase 1, Alpha; CaM-Kinase Kinase Alpha; CaM-Kinase IV Kinase; CaM-Kinase Kinase 1; CaM-KK Alpha; CaM-KK 1;
Function
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
Biological Process
Chemical synaptic transmission Source: Reactome
Intracellular signal transduction Source: GO_Central
Positive regulation of protein kinase activity Source: GO_Central
Cellular Location
Cytoplasm; Nucleus
PTM
Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity).

Beghi, S., Cavaliere, F., Manfredini, M., Ferrarese, S., Corazzari, C., Beghi, C., & Buschini, A. (2021). Polymorphism rs7214723 in CAMKK1: a new genetic variant associated with cardiovascular diseases. Bioscience Reports, 41(7), BSR20210326.

Mikulů, M. (2020). Studium struktury komplexů proteinu 14-3-3 s CaMKK1 a CaMKK1: Ca2+/CaM.

Prajisha, J., Biswal, J., & Jeyakanthan, J. (2020). Discovery of potent Camkk1 kinase inhibitors through e-pharmacophore and molecular screening approaches. Journal of Biomolecular Structure and Dynamics, 1-17.

AdS, S., Couñago, R. M., Godoi, P. H. C., Massirer, K. B., Gileadi, O., & Elkins, J. M. (2018). Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors.

da Silva Santiago, A., Couñago, R. M., Ramos, P. Z., Godoi, P. H., Massirer, K. B., Gileadi, O., & Elkins, J. M. (2018). Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors. Scientific reports, 8(1), 1-10.

Dong, F., Patnaik, S., Duan, Z. H., Kiedrowski, M., Penn, M. S., & Mayorga, M. E. (2017). A novel role for CAMKK1 in the regulation of the mesenchymal stem cell secretome. Stem cells translational medicine, 6(9), 1759-1766.

Wang, J., Lan, X., Jiang, S., Ma, Y., Zhang, S., Li, Y., ... & Lan, H. (2017). CaMKK1 from Chenopodium album positively regulates salt and drought tolerance in transgenic tobacco. Plant Cell, Tissue and Organ Culture (PCTOC), 130(1), 209-225.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

CAMKK1 Matched Antibody Pair (176) (CAT#: APMAB-176LY)

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CAMKK1 Matched Antibody Pair (176) (CAT#: APMAB-176LY)

Mouse Anti-CAMKK1 Recombinant Antibody (CBYY-C0918) (CAT#: CBMAB-C2355-YY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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