Rat Recombinant CAMKK1, Active protein, GST Tag (V2LY-0526-LY9196)

Name: Rat Recombinant CAMKK1, Active protein, GST Tag
SKU: V2LY-0526-LY9196
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Rat

Tag

GST Tag

Protein Construction

This product is Rat Recombinant CAMKK1, Active protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 88 kDa.

Molecule Mass

88 kDa

Sequence

Amino Acid: Full Length

Species

Rat

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Calcium/Calmodulin Dependent Protein Kinase Kinase 1

Function

Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.

Biological Process

Chemical synaptic transmission Source: Reactome
Intracellular signal transduction Source: GO_Central
Positive regulation of protein kinase activity Source: GO_Central

Cellular Location

Cytoplasm; Nucleus

PTM

Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity).

Beghi, S., Cavaliere, F., Manfredini, M., Ferrarese, S., Corazzari, C., Beghi, C., & Buschini, A. (2021). Polymorphism rs7214723 in CAMKK1: a new genetic variant associated with cardiovascular diseases. Bioscience Reports, 41(7), BSR20210326.

Mikulů, M. (2020). Studium struktury komplexů proteinu 14-3-3 s CaMKK1 a CaMKK1: Ca2+/CaM.

Prajisha, J., Biswal, J., & Jeyakanthan, J. (2020). Discovery of potent Camkk1 kinase inhibitors through e-pharmacophore and molecular screening approaches. Journal of Biomolecular Structure and Dynamics, 1-17.

AdS, S., Couñago, R. M., Godoi, P. H. C., Massirer, K. B., Gileadi, O., & Elkins, J. M. (2018). Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors.

da Silva Santiago, A., Couñago, R. M., Ramos, P. Z., Godoi, P. H., Massirer, K. B., Gileadi, O., & Elkins, J. M. (2018). Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors. Scientific reports, 8(1), 1-10.

Dong, F., Patnaik, S., Duan, Z. H., Kiedrowski, M., Penn, M. S., & Mayorga, M. E. (2017). A novel role for CAMKK1 in the regulation of the mesenchymal stem cell secretome. Stem cells translational medicine, 6(9), 1759-1766.

Wang, J., Lan, X., Jiang, S., Ma, Y., Zhang, S., Li, Y., ... & Lan, H. (2017). CaMKK1 from Chenopodium album positively regulates salt and drought tolerance in transgenic tobacco. Plant Cell, Tissue and Organ Culture (PCTOC), 130(1), 209-225.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CAMKK1, Active protein, GST Tag (CAT#: V2LY-0526-LY2542)

Rat Recombinant CAMKK1 (F230G) protein, GST Tag (CAT#: V2LY-0526-LY9195)

CAMKK1 Matched Antibody Pair (176) (CAT#: APMAB-176LY)

Antibody Pairs

CAMKK1 Matched Antibody Pair (176) (CAT#: APMAB-176LY)

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Mouse Anti-CAMKK1 Recombinant Antibody (CBFYC-0777) (CAT#: CBMAB-C0832-FY)

Mouse Anti-CAMKK1 Recombinant Antibody (CBXC-2003) (CAT#: CBMAB-C5528-CQ)

Human Recombinant CAMKK1, Active protein, GST Tag (CAT#: V2LY-0526-LY2542)

CAMKK1 Matched Antibody Pair (176) (CAT#: APMAB-176LY)

Rat Recombinant CAMKK1 (F230G) protein, GST Tag (CAT#: V2LY-0526-LY9195)

Mouse Anti-CAMKK1 Recombinant Antibody (4B4) (CAT#: CBMAB-C6654-LY)

Mouse Anti-CAMKK1 Recombinant Antibody (CBYY-C0918) (CAT#: CBMAB-C2355-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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