CAPN2

CAPN2 (Calpain 2) is a Protein Coding gene. Diseases associated with CAPN2 include Alzheimer Disease. Among its related pathways are Integrin Pathway and Necroptosis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and peptidase activity. An important paralog of this gene is CAPN1.

Calpain 2

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508).
Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).

Behavioral response to pain Source: Ensembl
Blastocyst development Source: Ensembl
Cellular response to amino acid stimulus Source: UniProtKB
Cellular response to interferon-beta Source: Ensembl
Cellular response to lipopolysaccharide Source: Ensembl
Extracellular matrix disassembly Source: Reactome
Female pregnancy Source: Ensembl
Myoblast fusion Source: Ensembl
Positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
Positive regulation of myoblast fusion Source: Ensembl
Positive regulation of neuron death Source: Ensembl
Positive regulation of phosphatidylcholine biosynthetic process Source: Ensembl
Protein autoprocessing Source: Ensembl
Proteolysis Source: UniProtKB
Proteolysis involved in cellular protein catabolic process Source: BHF-UCL
Regulation of cytoskeleton organization Source: BHF-UCL
Regulation of interleukin-6 production Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to hypoxia Source: Ensembl

Cytoplasm; Cell membrane. Translocates to the plasma membrane upon Ca2+ binding.