CASP8AP2

CASP8AP2 (Caspase 8 Associated Protein 2) is a Protein Coding gene. Among its related pathways are TNFR1 Pathway and Apoptosis and survival Caspase cascade. Gene Ontology (GO) annotations related to this gene include identical protein binding and protease binding.

Full Name

CASP8AP2

Function

Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.

Biological Process

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Apoptotic signaling pathway Source: ProtInc
Cell cycle Source: UniProtKB-KW
Cellular response to mechanical stimulus Source: UniProtKB
Extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
Fas signaling pathway Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Cytoplasm; Mitochondrion; Nucleus; PML body. Exported from the nucleus to the mitochondria upon FAS activation.