Sign in or Register   Sign in or Register
  |  

Mouse Anti-CASP8AP2 Antibody (1D2) (CBMAB-0186-YC)

Provided herein are mouse monoclonal antibodies against Human CASP8AP2. The antibody clone 1D2 can be used for immunoassay techniques, such as ELISA, IP and WB.
See all CASP8AP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D2
Antibody Isotype
IgG2b
Application
ELISA, IP, WB

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CASP8AP2
Introduction
CASP8AP2 (caspase 8 associated protein 2) is a protein that in humans is encoded by the CASP8AP2 gene. CASP8AP2 is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. This protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.
Entrez Gene ID
9994
UniProt ID
Q9UKL3
Alternative Names
CED-4; FLASH; FLJ11208; KIAA1315; RIP25
Function
Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Apoptotic signaling pathway Source: ProtInc
Cell cycle Source: UniProtKB-KW
Cellular response to mechanical stimulus Source: UniProtKB
Extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
Fas signaling pathway Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Cytoplasm; Mitochondrion; Nucleus; PML body. Exported from the nucleus to the mitochondria upon FAS activation.

Abaandou, L., Sharma, A. K., & Shiloach, J. (2021). Knockout of the caspase 8‐associated protein 2 gene improves recombinant protein expression in HEK293 cells through up‐regulation of the cyclin‐dependent kinase inhibitor 2A gene. Biotechnology and Bioengineering, 118(1), 186-198.

Wu, T. Y., Leng, Q., & Tian, L. Q. (2021). The microRNA-210/Casp8ap2 Axis Alleviates Hypoxia-Induced Myocardial Injury by Regulating Apoptosis and Autophagy. Cytogenetic and Genome Research, 1-11.

Ibrahimova, A., Luebbering, N., Abdullah, S., Lane, A., Duell, A., Lake, K. E., ... & Myers, K. C. (2021, February). Dysregulation of Hypoxia Induced Factor 1 Alpha (HIF1α) and Caspase 8 Associated Protein 2 (CASP8AP2) in Patients with Graft Versus Host Disease (GVHD). In 2021 TCT| Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR. TCT Meetings.

Yu, X., Liu, F., Liu, Y., Bai, B., Yin, H., Wang, H., ... & Geng, Q. (2021). Omega-3 fatty acid protects cardiomyocytes against hypoxia-induced injury through targeting MiR-210-3p/CASP8AP2 axis. Molecular and Cellular Biochemistry, 1-9.

Li, K., Pan, J., Li, Q., Li, S., Cheng, Y., Chai, L., ... & Bai, Y. (2020, October). The MicroRNA-210/Casp8ap2 Pathway Alleviates Hypoxia-Induced Injury in Myocardial Cells by Regulating Apoptosis and Autophagy. In The Heart Surgery Forum (Vol. 23, No. 6, pp. E797-E802).

Liu, F. F., Wang, K. L., Deng, L. P., Liu, X., Wu, M. Y., Wang, T. Y., ... & Li, Z. G. (2018). Transcription factor E2F3a regulates CASP8AP2 transcription and enhances sensitivity to chemotherapeutic drugs in acute lymphoblastic leukemia. Cancer cell international, 18(1), 1-9.

Mei, Y., Li, Z., Zhang, Y., Zhang, W., Hu, H., Zhang, P., ... & Huang, D. (2017). Low miR‑210 and CASP8AP2 expression is associated with a poor outcome in pediatric acute lymphoblastic leukemia. Oncology letters, 14(6), 8072-8077.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CASP8AP2 Antibody (1D2)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare