CCL8

CCL8 (C-C Motif Chemokine Ligand 8) is a Protein Coding gene. Diseases associated with CCL8 include Diffuse Gastric Cancer. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase activity and chemokine activity. An important paralog of this gene is CCL11.

Full Name

C-C Motif Chemokine Ligand 8

Function

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Calcium ion transport Source: UniProtKB
Cell-cell signaling Source: UniProtKB
Cellular calcium ion homeostasis Source: UniProtKB
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Eosinophil chemotaxis Source: GO_Central
Exocytosis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Negative regulation by host of viral genome replication Source: ARUK-UCL
Negative regulation of leukocyte proliferation Source: Ensembl
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of leukocyte migration Source: Ensembl
Response to virus Source: ProtInc
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.