CD109

CD109 (CD109 Molecule) is a Protein Coding gene. Diseases associated with CD109 include Fetal And Neonatal Alloimmune Thrombocytopenia and Vulva Squamous Cell Carcinoma. Among its related pathways are Metabolism of proteins and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and transforming growth factor beta binding. An important paralog of this gene is CPAMD8.

CD109 Molecule

Modulates negatively TGFB1 signaling in keratinocytes.

Hair follicle development Source: Ensembl
Negative regulation of keratinocyte proliferation Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Negative regulation of wound healing Source: UniProtKB
Osteoclast fusion Source: Ensembl
Platelet degranulation Source: Reactome
Regulation of keratinocyte differentiation Source: Ensembl

Cell membrane

N-glycosylated.
2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.