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Mouse Anti-CD109 Recombinant Antibody (B-E47) (CBMAB-C9972-LY)

The product is antibody recognizes CD109. The antibody B-E47 immunoassay techniques such as: FC.
See all CD109 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
B-E47
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD109 Molecule
Introduction
CD109 (CD109 Molecule) is a Protein Coding gene. Diseases associated with CD109 include Fetal And Neonatal Alloimmune Thrombocytopenia and Vulva Squamous Cell Carcinoma. Among its related pathways are Metabolism of proteins and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and transforming growth factor beta binding. An important paralog of this gene is CPAMD8.
Entrez Gene ID
135228
UniProt ID
Q6YHK3
Alternative Names
CD109 Molecule; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 7; 150 KDa TGF-Beta-1-Binding Protein; Platelet-Specific Gov Antigen; CD109 Antigen; CPAMD7;
Function
Modulates negatively TGFB1 signaling in keratinocytes.
Biological Process
Hair follicle development Source: Ensembl
Negative regulation of keratinocyte proliferation Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Negative regulation of wound healing Source: UniProtKB
Osteoclast fusion Source: Ensembl
Platelet degranulation Source: Reactome
Regulation of keratinocyte differentiation Source: Ensembl
Cellular Location
Cell membrane
PTM
N-glycosylated.
2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.

Merle, N. S., Kolev, M., Rahman, J., West, E., Yan, B., Kazemian, M., ... & Kemper, C. (2021). The C3-like molecule CD109 controls Th1 versus Th17 induction in CD4+ T cells.

Lee, K. Y., Kuo, T. C., Chou, C. M., Hsu, W. J., Lee, W. C., Dai, J. Z., ... & Lin, C. W. (2021). Upregulation of CD109 Promotes the Epithelial-to-Mesenchymal Transition and Stemness Properties of Lung Adenocarcinomas via Activation of the Hippo-YAP Signaling. Cells, 10(1), 28.

Li, C., Cho, H. J., Yamashita, D., Abdelrashid, M., Chen, Q., Bastola, S., ... & Nakano, I. (2020). Tumor edge-to-core transition promotes malignancy in primary-to-recurrent glioblastoma progression in a PLAGL1/CD109-mediated mechanism. Neuro-oncology advances, 2(1), vdaa163.

Lee, K. Y., Shueng, P. W., Chou, C. M., Lin, B. X., Lin, M. H., Kuo, D. Y., ... & Lin, C. W. (2020). Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR‐AKT‐mTOR signaling. Cancer science, 111(5), 1652.

Hatsuzawa, Y., Yamaguchi, K., Takanashi, T., Sato, I., Tamai, K., Mochizuki, M., ... & Sugamura, K. (2020). CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells. Pancreatology, 20(3), 493-500.

Zhou, S., da Silva, S. D., Siegel, P. M., & Philip, A. (2019). CD109 acts as a gatekeeper of the epithelial trait by suppressing epithelial to mesenchymal transition in squamous cell carcinoma cells in vitro. Scientific reports, 9(1), 1-17.

Mii, S., Enomoto, A., Shiraki, Y., Taki, T., Murakumo, Y., & Takahashi, M. (2019). CD109: a multifunctional GPI‐anchored protein with key roles in tumor progression and physiological homeostasis. Pathology international, 69(5), 249-259.

Qi, R., Dong, F., Liu, Q., Murakumo, Y., & Liu, J. (2018). CD109 and squamous cell carcinoma. Journal of translational medicine, 16(1), 1-8.

Chuang, C. H., Greenside, P. G., Rogers, Z. N., Brady, J. J., Yang, D., Ma, R. K., ... & Winslow, M. M. (2017). Molecular definition of a metastatic lung cancer state reveals a targetable CD109–Janus kinase–Stat axis. Nature medicine, 23(3), 291-300.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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