Rabbit Anti-CD109 Recombinant Antibody (CBXC-1827) (CBMAB-C5460-CQ)

Name: Rabbit Anti-CD109 Recombinant Antibody (CBXC-1827)
SKU: CBMAB-C5460-CQ
Rating: 5 (1 reviews)

See all CD109 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXC-1827

Application

Immunogen

Recombinant protein of human CD109.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 0.05% BSA, 50% glycerol

Preservative

0.05% sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

CD109 Molecule

Introduction

CD109 (CD109 Molecule) is a Protein Coding gene. Diseases associated with CD109 include Fetal And Neonatal Alloimmune Thrombocytopenia and Vulva Squamous Cell Carcinoma. Among its related pathways are Metabolism of proteins and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and transforming growth factor beta binding. An important paralog of this gene is CPAMD8.

Entrez Gene ID

135228

UniProt ID

Q6YHK3

Function

Modulates negatively TGFB1 signaling in keratinocytes.

Biological Process

Hair follicle development Source: Ensembl
Negative regulation of keratinocyte proliferation Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Negative regulation of wound healing Source: UniProtKB
Osteoclast fusion Source: Ensembl
Platelet degranulation Source: Reactome
Regulation of keratinocyte differentiation Source: Ensembl

Cellular Location

Cell membrane

PTM

N-glycosylated.
2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.

Merle, N. S., Kolev, M., Rahman, J., West, E., Yan, B., Kazemian, M., ... & Kemper, C. (2021). The C3-like molecule CD109 controls Th1 versus Th17 induction in CD4+ T cells.

Lee, K. Y., Kuo, T. C., Chou, C. M., Hsu, W. J., Lee, W. C., Dai, J. Z., ... & Lin, C. W. (2021). Upregulation of CD109 Promotes the Epithelial-to-Mesenchymal Transition and Stemness Properties of Lung Adenocarcinomas via Activation of the Hippo-YAP Signaling. Cells, 10(1), 28.

Li, C., Cho, H. J., Yamashita, D., Abdelrashid, M., Chen, Q., Bastola, S., ... & Nakano, I. (2020). Tumor edge-to-core transition promotes malignancy in primary-to-recurrent glioblastoma progression in a PLAGL1/CD109-mediated mechanism. Neuro-oncology advances, 2(1), vdaa163.

Lee, K. Y., Shueng, P. W., Chou, C. M., Lin, B. X., Lin, M. H., Kuo, D. Y., ... & Lin, C. W. (2020). Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR‐AKT‐mTOR signaling. Cancer science, 111(5), 1652.

Hatsuzawa, Y., Yamaguchi, K., Takanashi, T., Sato, I., Tamai, K., Mochizuki, M., ... & Sugamura, K. (2020). CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells. Pancreatology, 20(3), 493-500.

Zhou, S., da Silva, S. D., Siegel, P. M., & Philip, A. (2019). CD109 acts as a gatekeeper of the epithelial trait by suppressing epithelial to mesenchymal transition in squamous cell carcinoma cells in vitro. Scientific reports, 9(1), 1-17.

Mii, S., Enomoto, A., Shiraki, Y., Taki, T., Murakumo, Y., & Takahashi, M. (2019). CD109: a multifunctional GPI‐anchored protein with key roles in tumor progression and physiological homeostasis. Pathology international, 69(5), 249-259.

Qi, R., Dong, F., Liu, Q., Murakumo, Y., & Liu, J. (2018). CD109 and squamous cell carcinoma. Journal of translational medicine, 16(1), 1-8.

Chuang, C. H., Greenside, P. G., Rogers, Z. N., Brady, J. J., Yang, D., Ma, R. K., ... & Winslow, M. M. (2017). Molecular definition of a metastatic lung cancer state reveals a targetable CD109–Janus kinase–Stat axis. Nature medicine, 23(3), 291-300.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rabbit Anti-CD109 Recombinant Antibody (CBXC-1827)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-CD109 Recombinant Antibody (CBT4639) (CAT#: V2LY-0625-LY1692)

Mouse Anti-CD109 Recombinant Antibody (496920) (CAT#: CBMAB-C1362-LY)

Mouse Anti-CD109 Recombinant Antibody (CBT3916) (CAT#: V2LY-0625-LY1057)

Mouse Anti-CD109 Recombinant Antibody (CBXC-2777) (CAT#: CBMAB-C5459-CQ)

Mouse Anti-CD109 Recombinant Antibody (CBT4171) (CAT#: V2LY-0625-LY1693)

Mouse Anti-CD109 Recombinant Antibody (W7C5) (CAT#: CBMAB-C9972-LY)

Mouse Anti-CD109 Recombinant Antibody (CBFYC-1100) (CAT#: CBMAB-C1157-FY)

Mouse Anti-CD109 Recombinant Antibody (CBFYC-1101) (CAT#: CBMAB-C1158-FY)

Mouse Anti-CD109 Recombinant Antibody (CBCNC-158) (CAT#: CBMAB-C1514-CN)

Rabbit Anti-CD109 Recombinant Antibody (C7140) (CAT#: CBMAB-C7140-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry