CDC20

CDC20 (Cell Division Cycle 20) is a Protein Coding gene. Diseases associated with CDC20 include Uterine Corpus Endometrial Carcinoma. Among its related pathways are Metabolism of proteins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include enzyme binding and protein C-terminus binding. An important paralog of this gene is FZR1.

Full Name

Cell Division Cycle 20

Function

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Biological Process

Anaphase-promoting complex-dependent catabolic process Source: UniProtKB
Cell differentiation Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Mitotic sister chromatid cohesion Source: Ensembl
Mitotic spindle assembly Source: Ensembl
Mitotic spindle assembly checkpoint Source: Reactome
Mitotic spindle organization Source: Reactome
Nervous system development Source: UniProtKB-KW
Positive regulation of anaphase-promoting complex-dependent catabolic process Source: GO_Central
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of synapse maturation Source: UniProtKB
Positive regulation of synaptic plasticity Source: UniProtKB
Positive regulation of ubiquitin protein ligase activity Source: UniProtKB
Protein deubiquitination Source: Reactome
Protein ubiquitination Source: UniProtKB-UniPathway
Regulation of dendrite development Source: Ensembl
Regulation of exit from mitosis Source: Reactome
Regulation of meiotic nuclear division Source: Ensembl
Regulation of mitotic cell cycle phase transition Source: Reactome
Ubiquitin-dependent protein catabolic process Source: Reactome

Cellular Location

Centrosome; Spindle pole

PTM

Acetylated. Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).
Phosphorylated during mitosis, probably by maturation promoting factor (MPF). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161. Phosphorylated by NEK2.
Dephosphorylated by CTDP1.
Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Deubiquitinated by USP44, leading to stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C. Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex.