CDKN2D

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq]
Full Name
Cyclin Dependent Kinase Inhibitor 2D
Function
Interacts strongly with CDK4 and CDK6 and inhibits them.
Biological Process
Autophagic cell death Source: BHF-UCL
Cell cycle arrest Source: BHF-UCL
DNA synthesis involved in DNA repair Source: BHF-UCL
G1/S transition of mitotic cell cycle Source: BHF-UCL
Negative regulation of cell growth Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycle Source: Reactome
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
Negative regulation of phosphorylation Source: BHF-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Response to retinoic acid Source: BHF-UCL
Response to UV Source: BHF-UCL
Response to vitamin D Source: BHF-UCL
Sensory perception of sound Source: Ensembl
Cellular Location
Nucleus; Cytoplasm
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Anti-CDKN2D antibodies

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Mouse Anti-CDKN2D Recombinant Antibody (CBXC-0349) (CBMAB-C5164-CQ)

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Target: CDKN2D
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse, Rat
Clone: CBXC-0349
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CDKN2D Recombinant Antibody (CBXC-0348) (CBMAB-C5163-CQ)

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Target: CDKN2D
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat
Clone: CBXC-0348
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CDKN2D Recombinant Antibody (P0213) (CBMAB-P0213-YC)

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Target: CDKN2D
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: P0213
Application*: WB, IP, E
Datasheet SDS

Mouse Anti-CDKN2D Recombinant Antibody (CBFYC-1650) (CBMAB-C1711-FY)

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Target: CDKN2D
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Mouse, Rat
Clone: CBFYC-1650
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CDKN2D Recombinant Antibody (CBFYC-1649) (CBMAB-C1710-FY)

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Target: CDKN2D
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1649
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CDKN2D Recombinant Antibody (DCS-100) (CBMAB-C9343-LY)

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Target: CDKN2D
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: DCS-100
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CDKN2D Recombinant Antibody (3H2796) (CBMAB-C6294-LY)

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Target: CDKN2D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H2796
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CDKN2D Recombinant Antibody (C4953) (CBMAB-C4953-LY)

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Target: CDKN2D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C4953
Application*: E
Datasheet SDS

Mouse Anti-CDKN2D Recombinant Antibody (C2942) (CBMAB-C2942-LY)

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Target: CDKN2D
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: C2942
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CDKN2D Recombinant Antibody (06) (CBMAB-C1812-LY)

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Target: CDKN2D
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 06
Application*: WB, IP, IF, E
Datasheet SDS

CDKN2D Matched Antibody Pair (249) (APMAB-249LY)

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Target: CDKN2D
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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