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Mouse Anti-CDKN2D Recombinant Antibody (CBFYC-1649) (CBMAB-C1710-FY)

This product is mouse antibody that recognizes CDKN2D. The antibody CBFYC-1649 can be used for immunoassay techniques such as: IHC, WB.
See all CDKN2D antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1649
Antibody Isotype
IgG
Application
IHC, WB

Basic Information

Immunogen
Recombinant protein corresponding to human Cyclin-dependent Kinase 4 Inhibitor D, purified from E.coli
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, 2% BSA
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cyclin Dependent Kinase Inhibitor 2D
Introduction
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.
Entrez Gene ID
1032
UniProt ID
P55273
Alternative Names
p19; INK4D; p19-INK4D
Function
Interacts strongly with CDK4 and CDK6 and inhibits them.
Biological Process
Autophagic cell death Source: BHF-UCL
Cell cycle arrest Source: BHF-UCL
DNA synthesis involved in DNA repair Source: BHF-UCL
G1/S transition of mitotic cell cycle Source: BHF-UCL
Negative regulation of cell growth Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycle Source: Reactome
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
Negative regulation of phosphorylation Source: BHF-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Response to retinoic acid Source: BHF-UCL
Response to UV Source: BHF-UCL
Response to vitamin D Source: BHF-UCL
Sensory perception of sound Source: Ensembl
Cellular Location
Nucleus; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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