Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-CDKN2D Recombinant Antibody (CBFYC-1649) (CBMAB-C1710-FY)


See all CDKN2D antibodies
Online Inquiry
Published Data
CBMAB-C1710-FY-1
Mouse Anti-CDKN2D Recombinant Antibody (CBFYC-1649) (CBMAB-C1710-FY) in WB
Western blotting for Sirt1, VDR, TGF-β1, TGF-β RII, Smad2, p-Smad2(Ser465/467), p-Smad2/3(Ser423/425), Snail, Collagen 1, IL-11, IL-11Rα1, MEK1/2, p-MEK1/2(Ser217/221), ERK1/2, p-ERK1/2 (Thr202/Tyr204), eIF4E, p-elF4E(Ser209), p16, p19, p21, p53, acetyl-histone H3(Lys9/Lys14), and α-SMA. β-actin was used as the loading control. ...View More
Zhou, J., Chen, H., Wang, Q., Chen, S., Wang, R., Wang, Z., ... & Jin, J. (2022). Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription. Aging Cell, 21(8), e13680.
Distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
CBMAB-C1710-FY-2
Mouse Anti-CDKN2D Recombinant Antibody (CBFYC-1649) (CBMAB-C1710-FY) in WB
Representative western blots showing renal expression of p19ARF and fibronectin in three groups, as indicated. ...View More
Meng, P., Huang, J., Ling, X., Zhou, S., Wei, J., Zhu, M., ... & Zhou, L. (2022). CXC chemokine receptor 2 accelerates tubular cell senescence and renal fibrosis via β-catenin-induced mitochondrial dysfunction. Frontiers in Cell and Developmental Biology, 10, 862675.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-C1710-FY-3
Mouse Anti-CDKN2D Recombinant Antibody (CBFYC-1649) (CBMAB-C1710-FY) in WB
Western blot was performed to examine the relative expression of Tax and p19 in neurospheres co-cultured with HTLV-1 infected cells with or without IFN/AZT treatment. ...View More
Branscome, H., Khatkar, P., Al Sharif, S., Yin, D., Jacob, S., Cowen, M., ... & Kashanchi, F. (2022). Retroviral infection of human neurospheres and use of stem Cell EVs to repair cellular damage. Scientific reports, 12(1), 2019.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-C1710-FY-4
Mouse Anti-CDKN2D Recombinant Antibody (CBFYC-1649) (CBMAB-C1710-FY) in WB
Western blot analysis of the expression of cell cycle-related proteins in FD-LSC-1 cells. ...View More
Yang, J., Huang, Q., Guo, Y., Wei, Z., Zhou, L., & Chen, H. (2021). DIAPH1 promotes laryngeal squamous cell carcinoma progression through cell cycle regulation. Frontiers in Oncology, 11, 716876.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-C1710-FY-5
Mouse Anti-CDKN2D Recombinant Antibody (CBFYC-1649) (CBMAB-C1710-FY) in WB
Subpopulations (2 k, 10 k and 100 k EVs), were analyzed via Western blot for cell surface proteins (CD45, CD43, ICAM-1, LFA-1), HTLV-1 proteins (gp46, and p19), EVs (CD63), and Actin. ...View More
Pinto, D. O., Al Sharif, S., Mensah, G., Cowen, M., Khatkar, P., Erickson, J., ... & Kashanchi, F. (2021). Extracellular vesicles from HTLV-1 infected cells modulate target cells and viral spread. Retrovirology, 18, 1-27.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-C1710-FY-6
Mouse Anti-CDKN2D Recombinant Antibody (CBFYC-1649) (CBMAB-C1710-FY) in WB
Western blots of pulmonary extracts showing p16, p19, p53, p21, and 8-OHdG. β-actin was used as the loading control. ...View More
Chen, H., Chen, H., Liang, J., Gu, X., Zhou, J., Xie, C., ... & Jin, J. (2020). TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency. Experimental & Molecular Medicine, 52(1), 130-151.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYC-1649
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 1-166 representing full length p19 INK4D of mouse.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cyclin Dependent Kinase Inhibitor 2D
Introduction
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.
Entrez Gene ID
1032
UniProt ID
P55273
Alternative Names
p19; INK4D; p19-INK4D
Function
Interacts strongly with CDK4 and CDK6 and inhibits them.
Biological Process
Autophagic cell death Source: BHF-UCL
Cell cycle arrest Source: BHF-UCL
DNA synthesis involved in DNA repair Source: BHF-UCL
G1/S transition of mitotic cell cycle Source: BHF-UCL
Negative regulation of cell growth Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycle Source: Reactome
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
Negative regulation of phosphorylation Source: BHF-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Response to retinoic acid Source: BHF-UCL
Response to UV Source: BHF-UCL
Response to vitamin D Source: BHF-UCL
Sensory perception of sound Source: Ensembl
Cellular Location
Nucleus; Cytoplasm
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CDKN2D Recombinant Antibody (CBFYC-1649)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry