Mouse Anti-CDKN2D Recombinant Antibody (DCS-100) (CBMAB-C9343-LY)

Name: Mouse Anti-CDKN2D Recombinant Antibody (DCS-100)
SKU: CBMAB-C9343-LY
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-CDKN2D Recombinant Antibody (DCS-100) (CBMAB-C9343-LY) in Immunoblot

CDK inhibitor proteins were examined for their cellular levels by immunoblotting analysis. ...View More

Por, E., Byun, H. J., Lee, E. J., Lim, J. H., Jung, S. Y., Park, I., ... & Lee, H. (2010). The cancer/testis antigen CAGE with oncogenic potential stimulates cell proliferation by up-regulating cyclins D1 and E in an AP-1-and E2F-dependent manner. Journal of Biological Chemistry, 285(19), 14475-14485.

Distributed under Open Access license CC BY 4.0, without modification.

Datasheet

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

DCS-100

Application

WB, IP, IF, ELISA

Immunogen

Full length p19 INK4D of human.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cyclin Dependent Kinase Inhibitor 2D

Entrez Gene ID

1032

UniProt ID

P55273

Alternative Names

Cyclin Dependent Kinase Inhibitor 2D; Cyclin-Dependent Kinase Inhibitor 2D (P19, Inhibits CDK4); P19-INK4D; Cell Cycle Inhibitor, Nur77 Associating Protein; Cyclin-Dependent Kinase 4 Inhibitor D P19; Inhibitor Of Cyclin-Dependent Kinase 4d;

Function

Interacts strongly with CDK4 and CDK6 and inhibits them.

Biological Process

Autophagic cell death Source: BHF-UCL
Cell cycle arrest Source: BHF-UCL
DNA synthesis involved in DNA repair Source: BHF-UCL
G1/S transition of mitotic cell cycle Source: BHF-UCL
Negative regulation of cell growth Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycle Source: Reactome
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
Negative regulation of phosphorylation Source: BHF-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Response to retinoic acid Source: BHF-UCL
Response to UV Source: BHF-UCL
Response to vitamin D Source: BHF-UCL
Sensory perception of sound Source: Ensembl

Cellular Location

Nucleus; Cytoplasm

Dehkordi, S. K., Walker, J., Sah, E., Bennett, E., Atrian, F., Frost, B., ... & Orr, M. E. (2021). Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology. Nature Aging, 1-10.

Mamoor, S. (2021). CDKN2D (INK4D) is differentially expressed in the lymph nodes of patients with metastatic breast cancer.

Lee, H. A., Chu, K. B., Moon, E. K., & Quan, F. S. (2021). Histone Deacetylase Inhibitor-Induced CDKN2B and CDKN2D Contribute to G2/M Cell Cycle Arrest Incurred by Oxidative Stress in Hepatocellular Carcinoma Cells via Forkhead Box M1 Suppression. Journal of Cancer, 12(17), 5086.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

CDKN2D Matched Antibody Pair (249) (CAT#: APMAB-249LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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