CDON

CDON and BOC (MIM 608708) are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII; see MIM 135600) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.[supplied by OMIM

Full Name

Cell Adhesion Associated, Oncogene Regulated

Function

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

Biological Process

Anterior/posterior pattern specification Source: Ensembl
Cell adhesion Source: UniProtKB
Cell fate specification Source: Ensembl
Cerebral cortex development Source: Ensembl
Embryonic body morphogenesis Source: Ensembl
Embryonic retina morphogenesis in camera-type eye Source: Ensembl
Lens development in camera-type eye Source: Ensembl
Myoblast fusion Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Positive regulation of muscle cell differentiation Source: Reactome
Positive regulation of myoblast differentiation Source: InterPro
Positive regulation of neural precursor cell proliferation Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of protein phosphorylation Source: Ensembl
Positive regulation of skeletal muscle tissue development Source: Ensembl
Positive regulation of small GTPase mediated signal transduction Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of protein binding Source: Ensembl
Skeletal muscle satellite cell differentiation Source: Ensembl
Smoothened signaling pathway Source: Ensembl

Cellular Location

Cell membrane

Involvement in disease

Holoprosencephaly 11 (HPE11): A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.

Topology

Extracellular: 26-963
Helical: 964-984
Cytoplasmic: 985-1287

PTM

N-glycosylated.