Mouse Anti-CDON Recombinant Antibody (2G12) (CBMAB-C5152-LY)

Name: Mouse Anti-CDON Recombinant Antibody (2G12)
SKU: CBMAB-C5152-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2G12

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa1155-1264 from human CDON.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cell Adhesion Associated, Oncogene Regulated

Entrez Gene ID

50937

UniProt ID

Q4KMG0

Alternative Names

Cell Adhesion Associated, Oncogene Regulated; Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes; CDO; Surface Glycoprotein, Ig Superfamily Member; Cdon Homolog (Mouse); Cdon Homolog; CDON1; HPE11; ORCAM;

Function

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

Biological Process

Anterior/posterior pattern specification Source: Ensembl
Cell adhesion Source: UniProtKB
Cell fate specification Source: Ensembl
Cerebral cortex development Source: Ensembl
Embryonic body morphogenesis Source: Ensembl
Embryonic retina morphogenesis in camera-type eye Source: Ensembl
Lens development in camera-type eye Source: Ensembl
Myoblast fusion Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Positive regulation of muscle cell differentiation Source: Reactome
Positive regulation of myoblast differentiation Source: InterPro
Positive regulation of neural precursor cell proliferation Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of protein phosphorylation Source: Ensembl
Positive regulation of skeletal muscle tissue development Source: Ensembl
Positive regulation of small GTPase mediated signal transduction Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of protein binding Source: Ensembl
Skeletal muscle satellite cell differentiation Source: Ensembl
Smoothened signaling pathway Source: Ensembl

Cellular Location

Cell membrane

Involvement in disease

Holoprosencephaly 11 (HPE11): A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.

Topology

Extracellular: 26-963
Helical: 964-984
Cytoplasmic: 985-1287

PTM

N-glycosylated.

Chapouly, C., Hollier, P. L., Guimbal, S., Cornuault, L., Gadeau, A. P., & Renault, M. A. (2020). Desert hedgehog-driven endothelium integrity is enhanced by gas1 (growth arrest-specific 1) but negatively regulated by Cdon (cell adhesion molecule-related/downregulated by oncogenes). Arteriosclerosis, Thrombosis, and Vascular Biology, 40(12), e336-e349.

He, X., Lei, S., Zhang, Q., Ma, L., Li, N., & Wang, J. (2020). Deregulation of cell adhesion molecules is associated with progression and poor outcomes in endometrial cancer: Analysis of The Cancer Genome Atlas data. Oncology letters, 19(3), 1906-1914.

Wang, L. C., Kennedy, T. E., & Almazan, G. (2017). A novel function of TBK 1 as a target of Cdon in oligodendrocyte differentiation and myelination. Journal of neurochemistry, 140(3), 451-462.

Jeong, M. H., Kim, H. J., Pyun, J. H., Choi, K. S., Lee, D. I., Solhjoo, S., ... & Kang, J. S. (2017). Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling. Proceedings of the National Academy of Sciences, 114(8), E1345-E1354.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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