CERS2

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Full Name
Ceramide Synthase 2
Function
Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) chain as acyl donor. May regulate lipid metabolism in hepatocytes (By similarity).
Biological Process
Ceramide biosynthetic process Source: UniProtKB
Negative regulation of axon regeneration Source: BHF-UCL
Negative regulation of Schwann cell migration Source: BHF-UCL
Negative regulation of Schwann cell proliferation involved in axon regeneration Source: BHF-UCL
Regulation of lipid metabolic process Source: UniProtKB
Sphingolipid biosynthetic process Source: Reactome
Cellular Location
Endoplasmic reticulum membrane
Topology
Lumenal: 1-40
Helical: 41-61
Helical: 140-160
Helical: 181-201
Helical: 209-229
Helical: 264-284
Helical: 304-324
Cytoplasmic: 325-380
PTM
Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation.
Phosphorylated at the C-terminus by CK2, leading to increase the ceramide synthase activity.
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Anti-CERS2 antibodies

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Mouse Anti-CERS2 Recombinant Antibody (CBYJL-093) (CBMAB-L0149-YJ)

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Target: CERS2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-093
Application*: E, WB
Datasheet SDS

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-092) (CBMAB-L0148-YJ)

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Target: CERS2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse
Clone: CBYJL-092
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-091) (CBMAB-L0147-YJ)

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Target: CERS2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Zebrafish
Clone: CBYJL-091
Application*: WB, IH, IF
Datasheet SDS

Rabbit Anti-CERS2 Recombinant Antibody (CBYJL-090) (CBMAB-L0146-YJ)

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Target: CERS2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-090
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-089) (CBMAB-L0145-YJ)

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Target: CERS2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYJL-089
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-087) (CBMAB-L0143-YJ)

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Target: CERS2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Horse, Dog
Clone: CBYJL-087
Application*: WB, IP, IF, E, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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