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CERS2

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Full Name
Ceramide Synthase 2
Function
Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) chain as acyl donor. May regulate lipid metabolism in hepatocytes (By similarity).
Biological Process
Ceramide biosynthetic process Source: UniProtKB
Negative regulation of axon regeneration Source: BHF-UCL
Negative regulation of Schwann cell migration Source: BHF-UCL
Negative regulation of Schwann cell proliferation involved in axon regeneration Source: BHF-UCL
Regulation of lipid metabolic process Source: UniProtKB
Sphingolipid biosynthetic process Source: Reactome
Cellular Location
Endoplasmic reticulum membrane
Topology
Lumenal: 1-40
Helical: 41-61
Helical: 140-160
Helical: 181-201
Helical: 209-229
Helical: 264-284
Helical: 304-324
Cytoplasmic: 325-380
PTM
Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation.
Phosphorylated at the C-terminus by CK2, leading to increase the ceramide synthase activity.

Anti-CERS2 antibodies

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Mouse Anti-CERS2 Recombinant Antibody (CBWJC-2509) (CBMAB-C3580WJ)

Datasheet SDS
Target: CERS2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-2509
Application*: WB, IH

Mouse Anti-CERS2 Recombinant Antibody (CBWJC-2508) (CBMAB-C3579WJ)

Datasheet SDS
Target: CERS2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJC-2508
Application*: WB

Mouse Anti-CERS2 (AA 1-380) Recombinant Antibody (CBFYC-1731) (CBMAB-C1793-FY)

Datasheet SDS
Target: CERS2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBFYC-1731
Application*: E, WB

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-093) (CBMAB-L0149-YJ)

Datasheet SDS
Target: CERS2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-093
Application*: WB, P, IF, IC

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-092) (CBMAB-L0148-YJ)

Datasheet SDS
Target: CERS2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-092
Application*: WB, IH, IF, IC

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-091) (CBMAB-L0147-YJ)

Datasheet SDS
Target: CERS2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-091
Application*: WB

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-090) (CBMAB-L0146-YJ)

Datasheet SDS
Target: CERS2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-090
Application*: E, WB

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-089) (CBMAB-L0145-YJ)

Datasheet SDS
Target: CERS2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJL-089
Application*: E, WB

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-087) (CBMAB-L0143-YJ)

Datasheet SDS
Target: CERS2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBYJL-087
Application*: E, WB

Mouse Anti-CERS2 Recombinant Antibody (4D8) (CBMAB-A4864-LY)

Datasheet SDS
Target: CERS2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4D8
Application*: WB, E

Mouse Anti-CERS2 Recombinant Antibody (A102) (CBMAB-AP4183LY)

Datasheet SDS
Target: CERS2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: A102
Application*: ICC, IHC, WB

Mouse Anti-CERS2 Recombinant Antibody (CAP483) (CBMAB-AP1453LY)

Datasheet SDS
Target: CERS2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Zebrafish
Clone: CAP483
Application*: FC, IF, IHC, WB

Mouse Anti-CERS2 Recombinant Antibody (3G3) (CBMAB-C6134-LY)

Datasheet SDS
Target: CERS2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3G3
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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