CHORDC1

CHORDC1 (Cysteine And Histidine Rich Domain Containing 1) is a Protein Coding gene.

Full Name

Cysteine And Histidine Rich Domain Containing 1

Function

Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755).
Proposed to act as co-chaperone for HSP90 (PubMed:20230755).
May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755).
In vitro, has intrinsic chaperone activity (PubMed:20230755).
This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755).
Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105).
Involved in stress response (PubMed:20230755).
Prevents tumorigenesis (PubMed:20230755).

Biological Process

Centrosome duplication Source: GO_Central
Chaperone-mediated protein folding Source: UniProtKB
Negative regulation of Rho-dependent protein serine/threonine kinase activity Source: Ensembl
Regulation of cellular response to heat Source: UniProtKB
Regulation of centrosome duplication Source: Ensembl