Mouse Anti-CHORDC1 Recombinant Antibody (CBYY-C3165) (CBMAB-C4608-YY)

Name: Mouse Anti-CHORDC1 Recombinant Antibody (CBYY-C3165)
SKU: CBMAB-C4608-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-C3165

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 29-328 mapping within an internal region of CHP1 of human.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Cysteine And Histidine Rich Domain Containing 1

Entrez Gene ID

26973

UniProt ID

Q9UHD1

Alternative Names

AHUS5, ARMD9, ASPa, C3b, CPAMD1, HEL-S-62p, C3

Function

Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755).
Proposed to act as co-chaperone for HSP90 (PubMed:20230755).
May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755).
In vitro, has intrinsic chaperone activity (PubMed:20230755).
This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755).
Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105).
Involved in stress response (PubMed:20230755).
Prevents tumorigenesis (PubMed:20230755).

Biological Process

Centrosome duplication Source: GO_Central
Chaperone-mediated protein folding Source: UniProtKB
Negative regulation of Rho-dependent protein serine/threonine kinase activity Source: Ensembl
Regulation of cellular response to heat Source: UniProtKB
Regulation of centrosome duplication Source: Ensembl

He, X., Li, X., Han, Y., Chen, G., Xu, T., Cai, D., ... & Xiu, J. (2022). CircRNA Chordc1 protects mice from abdominal aortic aneurysm by contributing to the phenotype and growth of vascular smooth muscle cells. Molecular Therapy-Nucleic Acids, 27, 81-98.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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