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Mouse Anti-CHORDC1 Recombinant Antibody (CBYY-C3165) (CBMAB-C4608-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-C3165
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 29-328 mapping within an internal region of CHP1 of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cysteine And Histidine Rich Domain Containing 1
Entrez Gene ID
26973
UniProt ID
Q9UHD1
Alternative Names
AHUS5, ARMD9, ASPa, C3b, CPAMD1, HEL-S-62p, C3
Function
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755).
Proposed to act as co-chaperone for HSP90 (PubMed:20230755).
May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755).
In vitro, has intrinsic chaperone activity (PubMed:20230755).
This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755).
Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105).
Involved in stress response (PubMed:20230755).
Prevents tumorigenesis (PubMed:20230755).
Biological Process
Centrosome duplication Source: GO_Central
Chaperone-mediated protein folding Source: UniProtKB
Negative regulation of Rho-dependent protein serine/threonine kinase activity Source: Ensembl
Regulation of cellular response to heat Source: UniProtKB
Regulation of centrosome duplication Source: Ensembl
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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