CHRNB4

This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Cholinergic Receptor Nicotinic Beta 4 Subunit

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Chemical synaptic transmission Source: GO_Central
Ion transmembrane transport Source: GO_Central
Ion transport Source: UniProtKB
Nervous system process Source: GO_Central
Neutrophil degranulation Source: Reactome
Regulation of membrane potential Source: GO_Central
Regulation of neurotransmitter secretion Source: UniProtKB
Signal transduction Source: UniProtKB
Synaptic transmission, cholinergic Source: ProtInc
Synaptic transmission involved in micturition Source: UniProtKB

Postsynaptic cell membrane; Cell membrane

Extracellular: 22-236
Helical: 237-257
Cytoplasmic: 258-265
Helical: 266-286
Extracellular: 287-298
Helical: 299-319
Cytoplasmic: 320-460
Helical: 461-481
Extracellular: 482-498