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Mouse Anti-CHRNB4 Recombinant Antibody (CBXC-1771) (CBMAB-C4855-CQ)

This product is a mouse antibody that recognizes CHRNB4. The antibody CBXC-1771 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all CHRNB4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1771
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cholinergic Receptor Nicotinic Beta 4 Subunit
Introduction
This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
1143
UniProt ID
P30926
Alternative Names
Cholinergic Receptor Nicotinic Beta 4 Subunit; Acetylcholine Receptor, Nicotinic, Beta 4 (Neuronal); Cholinergic Receptor, Nicotinic, Beta Polypeptide 4; Cholinergic Receptor, Nicotinic, Beta 4 (Neuronal); Cholinergic Receptor, Nicotinic Beta 4;
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Biological Process
Chemical synaptic transmission Source: GO_Central
Ion transmembrane transport Source: GO_Central
Ion transport Source: UniProtKB
Nervous system process Source: GO_Central
Neutrophil degranulation Source: Reactome
Regulation of membrane potential Source: GO_Central
Regulation of neurotransmitter secretion Source: UniProtKB
Signal transduction Source: UniProtKB
Synaptic transmission, cholinergic Source: ProtInc
Synaptic transmission involved in micturition Source: UniProtKB
Cellular Location
Postsynaptic cell membrane; Cell membrane
Topology
Extracellular: 22-236
Helical: 237-257
Cytoplasmic: 258-265
Helical: 266-286
Extracellular: 287-298
Helical: 299-319
Cytoplasmic: 320-460
Helical: 461-481
Extracellular: 482-498
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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