CKMT1A

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]
Full Name
Creatine Kinase, Mitochondrial 1A
Function
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Biological Process
Creatine metabolic process Source: Reactome
Phosphocreatine biosynthetic process Source: GO_Central
Cellular Location
Mitochondrion inner membrane
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Anti-CKMT1A antibodies

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Mouse Anti-CKMT1A Recombinant Antibody (C2411) (CBMAB-C2411-CN)

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Target: CKMT1A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: C2411
Application*: WB, IP
Datasheet SDS

Mouse Anti-CKMT1A Recombinant Antibody (CBXC-2449) (CBMAB-C0047-CQ)

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Target: CKMT1A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-2449
Application*: WB, E
Datasheet SDS

Human Recombinant CKMT1A protein, His Tag (V2LY-0526-LY3193)

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Target: CKMT1A
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 40-417
Tag: His Tag
Datasheet SDS

Mouse Anti-CKMT1A Recombinant Antibody (
25E4) (V2LY-0725-LY276)

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Target: CKMT1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Rabbit, Mouse, Pig
Clone: 25E4
Application*: E, WB
Datasheet SDS

Mouse Anti-CKMT1A Recombinant Antibody (CBT1268) (V2LY-0625-LY2889)

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Target: CKMT1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Dog, Pig, Rabbit
Clone: CBT1268
Application*: WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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