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Mouse Anti-CKMT1A Recombinant Antibody (13k34) (CBMAB-C2411-CN)

This product is a Mouse antibody that recognizes CKMT1A. The antibody 13k34 can be used for immunoassay techniques such as: WB.
See all CKMT1A antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
13k34
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant human CKMT1 protein fragments expressed in E. coli
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, 50% glycerol
Preservative
0.2% Sodium azide

Target

Full Name
Creatine Kinase, Mitochondrial 1A
Introduction
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]
Entrez Gene ID
548596
UniProt ID
P12532
Alternative Names
Creatine Kinase, Mitochondrial 1A; Creatine Kinase, Mitochondrial 1 (Ubiquitous); Acidic-Type Mitochondrial Creatine Kinase; Ubiquitous Mitochondrial Creatine Kinase; EC 2.7.3.2; Mia-CK; U-MtCK;
Function
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Biological Process
Creatine metabolic process Source: Reactome
Phosphocreatine biosynthetic process Source: GO_Central
Cellular Location
Mitochondrion inner membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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