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CLDN12

Claudins, such as CLDN12, are components of epithelial cell tight junctions. Tight junctions regulate movement of solutes and ions through the paracellular space and prevent mixing of proteins and lipids in the outer leaflet of the apical and basolateral plasma membrane domains (Acharya et al., 2004).[supplied by OMIM

Full Name

claudin 12

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Biological Process

Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Maintenance of blood-brain barrier Source: ARUK-UCL

Cellular Location

Cell membrane; Tight junction

Topology

Cytoplasmic: 1-10
Helical: 11-31
Extracellular: 32-87
Helical: 88-108
Cytoplasmic: 109-135
Helical: 136-156
Extracellular: 157-174
Helical: 175-195
Cytoplasmic: 196-244

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Anti-CLDN12 antibodies

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Mouse Anti-CLDN12 Recombinant Antibody (CBXC-0450) (CBMAB-C5185-CQ)

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Target: CLDN12

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXC-0450

Application*: E

Mouse Anti-CLDN12 Recombinant Antibody (CBXC-1163) (CBMAB-C1429-CQ)

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Target: CLDN12

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-1163

Application*: F, IF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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