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CLTC

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]
Full Name
Clathrin Heavy Chain
Function
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582).

The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825).

Plays a role in early autophagosome formation (PubMed:20639872).
Biological Process
Amyloid-beta clearance by transcytosis Source: ARUK-UCL
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Autophagy Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Clathrin coat assembly Source: CAFA
Clathrin-dependent endocytosis Source: ARUK-UCL
Intracellular protein transport Source: UniProtKB
Low-density lipoprotein particle clearance Source: Reactome
Low-density lipoprotein particle receptor catabolic process Source: Reactome
Membrane organization Source: Reactome
Mitotic cell cycle Source: UniProtKB
Negative regulation of hyaluronan biosynthetic process Source: UniProtKB
Negative regulation of protein localization to plasma membrane Source: UniProtKB
Osteoblast differentiation Source: UniProtKB
Post-Golgi vesicle-mediated transport Source: Reactome
Receptor internalization Source: BHF-UCL
Receptor-mediated endocytosis Source: UniProtKB
Regulation of mitotic spindle organization Source: UniProtKB
Retrograde transport, endosome to Golgi Source: UniProtKB
Transferrin transport Source: BHF-UCL
Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Cellular Location
Spindle; Cytoplasmic vesicle membrane; Coated pit; Melanosome. Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.
Involvement in disease
Mental retardation, autosomal dominant 56 (MRD56):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

Anti-CLTC antibodies

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Target: CLTC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E5
Application*: E, WB
Target: CLTC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Pig
Clone: CBWJC-2825
Application*: WB, IP, IF
Target: CLTC
Host: Mouse
Antibody Isotype: IgM
Specificity: Rat, Cattle, Human, Pig
Clone: CHC5.9
Application*: WB, C
Target: CLTC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Pig, Rat
Clone: CBXC-2481
Application*: E, IF, WB
Target: CLTC
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Frog, Cattle, Pig, Rat
Clone: CHC 5.9
Application*: IC, IH, IP, WB
Target: CLTC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CLTC/1431
Application*: WB, F, IF
Target: CLTC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Chicken, Dog, Mouse, Rat
Clone: CBFYC-1963
Application*: WB, BI, IF, IH, IP
Target: CLTC
Host: Mouse
Antibody Isotype: IgM
Specificity: Cattle, Human, Mouse, Pig, Rat
Clone: CBFYC-1962
Application*: E, IF, IP, WB
Target: CLTC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 1B3D7
Application*: ELISA, WB
Target: CLTC
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: STo 3H9
Application*: WB
Target: CLTC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CBCNC-216
Application*: WB
Target: CLTC
Host: Mouse
Antibody Isotype: IgM
Specificity: Mouse
Clone: CBCNC-030
Application*: E, IF, IP, WB
Target: CLTC
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 3H9
Application*: WB
Target: CLTC
Host: Mouse
Antibody Isotype: IgM
Specificity: Dog
Clone: 2Q2166
Application*: C, WB
Target: CLTC
Host: Mouse
Antibody Isotype: IgM
Specificity: Mouse, Cattle, Human, Pig, Rat
Clone: 10B2250
Application*: E, IF, IP, WB
Target: CLTC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Zebrafish, Sheep, Frog, Dog
Clone: 3F133
Application*: IC/IF, P, IP, WB
Target: CLTC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human, Chicken, Dog, Mouse
Clone: 23/Clathrin Heavy Chain
Application*: WB, IF, IH, IP
Target: CLTC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Dog, Rat, Hamster, Cattle, Chicken
Clone: X22
Application*: B, E, F, IF, IH, P, IM, IP, WB
Target: CLTC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Mouse, Rat
Clone: TD.1
Application*: E, IF
Target: CLTC
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Mouse, Pig, Rat, Cattle
Clone: BF-06
Application*: E, F, IF, IP, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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