CREBL2

cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq]

Full Name

cAMP responsive element binding protein-like 2

Function

Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.

Biological Process

Cell cycle Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Positive regulation of fat cell differentiation Source: UniProtKB
Positive regulation of glucose import Source: UniProtKB
Positive regulation of lipid biosynthetic process Source: UniProtKB
Positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Protein stabilization Source: UniProtKB
Regulation of transcription, DNA-templated Source: GO_Central
Signal transduction Source: ProtInc
Transcription, DNA-templated Source: ProtInc

Cellular Location

Nucleus

PTM

Phosphorylated by AMPK.