DDX41

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017]
Full Name
DDX41
Function
Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing.
Biological Process
Apoptotic process Source: ProtInc
Cell differentiation Source: UniProtKB
Cell population proliferation Source: UniProtKB
mRNA splicing, via spliceosome Source: UniProtKB
Positive regulation of type I interferon production Source: Reactome
Cellular Location
Nucleus
Involvement in disease
Myeloproliferative/lymphoproliferative neoplasms, familial (MPLPF):
A familial cancer predisposition syndrome with incomplete penetrance, characterized by increased susceptibility to myeloid neoplasms and rarely to lymphoid malignancies. MPLPF inheritance is autosomal dominant.
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Anti-DDX41 antibodies

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Mouse Anti-DDX41 Monoclonal Antibody (1A10) (CBMAB-0283-YC)

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Target: DDX41
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 1A10
Application*: IP, WB
Datasheet SDS

Rabbit Anti-DDX41 Recombinant Antibody (CP0450) (V2LY-0425-LY81)

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Target: DDX41
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CP0450
Application*: WB, IP
Datasheet SDS

Mouse Anti-DDX41 Recombinant Antibody (1D4) (V2LY-0425-LY80)

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Target: DDX41
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D4
Application*: WB, E
Datasheet SDS

Mouse Anti-DDX41 Recombinant Antibody (1B4) (V2LY-0425-LY74)

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Target: DDX41
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B4
Application*: IF, WB, F
Datasheet SDS

Mouse Anti-DDX41 Recombinant Antibody (1D4) (CBMAB-A2162-LY)

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Target: DDX41
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D4
Application*: WB, E
Datasheet SDS

Mouse Anti-DDX41 Recombinant Antibody (D0578) (CBMAB-D0578-YC)

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Target: DDX41
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: D0578
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DDX41 Recombinant Antibody (CBYCD-222) (CBMAB-D0577-YC)

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Target: DDX41
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle
Clone: CBYCD-222
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DDX41 Recombinant Antibody (2F4) (CBMAB-D0574-YC)

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Target: DDX41
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F4
Application*: IF, WB, E
Datasheet SDS

Mouse Anti-DDX41 Recombinant Antibody (D0573) (CBMAB-D0573-YC)

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Target: DDX41
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Horse
Clone: D0573
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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