DECR2
DECR2 (2,4-Dienoyl-CoA Reductase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Peroxisome. Gene Ontology (GO) annotations related to this gene include receptor binding and 2,4-dienoyl-CoA reductase (NADPH) activity. An important paralog of this gene is DECR1.
Full Name
2,4-Dienoyl-CoA Reductase 2
Function
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
Biological Process
Fatty acid beta-oxidation using acyl-CoA oxidase Source: Reactome
Protein localization Source: Reactome
Unsaturated fatty acid biosynthetic process Source: UniProtKB
Protein localization Source: Reactome
Unsaturated fatty acid biosynthetic process Source: UniProtKB
Cellular Location
Peroxisome
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Anti-DECR2 antibodies
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Target: DECR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCD-233
Application*: E, WB
Target: DECR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4A7
Application*: WB
Target: DECR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCD-233
Application*: E, WB, IP
Target: DECR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4A7
Application*: E, WB, IF
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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