DIXDC1
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Full Name
DIX Domain Containing 1
Function
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
Biological Process
Canonical Wnt signaling pathway Source: UniProtKB
Cerebral cortex radially oriented cell migration Source: Ensembl
Forebrain ventricular zone progenitor cell division Source: Ensembl
Negative regulation of neuron differentiation Source: Ensembl
Positive regulation of Wnt signaling pathway Source: Ensembl
Regulation of actin cytoskeleton organization Source: Ensembl
Regulation of microtubule cytoskeleton organization Source: Ensembl
Cerebral cortex radially oriented cell migration Source: Ensembl
Forebrain ventricular zone progenitor cell division Source: Ensembl
Negative regulation of neuron differentiation Source: Ensembl
Positive regulation of Wnt signaling pathway Source: Ensembl
Regulation of actin cytoskeleton organization Source: Ensembl
Regulation of microtubule cytoskeleton organization Source: Ensembl
Cellular Location
Cytoplasm; Stress fiber; Focal adhesion. Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis (PubMed:19375513). Associated with actin stress fiber at the filament ends (PubMed:16814745).
Isoform 2: Cytoplasm. Not associated with stress fibers.
Isoform 2: Cytoplasm. Not associated with stress fibers.
PTM
Phosphorylated on tyrosine and serine residues.
Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation.
Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation.
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Anti-DIXDC1 antibodies
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CompareTarget: DIXDC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D7P6Q
Application*: WB
Target: DIXDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 6B6
Application*: WB, P, IC, IF
Target: DIXDC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B3
Application*: IF, WB
Target: DIXDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-32858
Application*: WB
Target: DIXDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D0962
Application*: WB
Target: DIXDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: 6B6
Application*: IF, WB, IH
Target: DIXDC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 1B3
Application*: IF, WB
Target: DIXDC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: D0958
Application*: WB, IP, IF, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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