DLG3

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Full Name
Discs Large MAGUK Scaffold Protein 3
Function
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
Biological Process
Cell-cell adhesion Source: GO_Central
Establishment of planar polarity Source: Ensembl
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Negative regulation of cell population proliferation Source: UniProtKB
Positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
Receptor clustering Source: GO_Central
Receptor localization to synapse Source: GO_Central
Regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl
Cellular Location
Cytosol; Extracellular space; AMPA glutamate receptor complex; Basolateral plasma membrane; Plasma membrane; Bicellular tight junction; Cell junction; Dendritic shaft; Glutamatergic synapse; Growth cone; Neuronal cell body; Postsynaptic density, intracellular component
Involvement in disease
Mental retardation, X-linked 90 (MRX90):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
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Anti-DLG3 antibodies

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Mouse Anti-DLG3 Recombinant Antibody (CBXS-5260) (V2LY-0425-LY447)

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Target: DLG3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBXS-5260
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DLG3 Recombinant Antibody (CBXS-4891) (V2LY-0425-LY446)

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Target: DLG3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Pig
Clone: CBXS-4891
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DLG3 Recombinant Antibody (2B6) (V2LY-0425-LY445)

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Target: DLG3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 2B6
Application*: E, WB
Datasheet SDS

Mouse Anti-DLG3 Recombinant Antibody (CBXS-3212) (CBMAB-CP2346-LY)

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Target: DLG3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-3212
Application*: WB, IP
Datasheet SDS

Mouse Anti-DLG3 Recombinant Antibody (CBXS-3211) (CBMAB-S5952-CQ)

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Target: DLG3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBXS-3211
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DLG3 Recombinant Antibody (3F2) (CBMAB-D1033-YC)

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Target: DLG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 3F2
Application*: F, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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