DLG3
This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Full Name
Discs Large MAGUK Scaffold Protein 3
Function
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
Biological Process
Cell-cell adhesion Source: GO_Central
Establishment of planar polarity Source: Ensembl
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Negative regulation of cell population proliferation Source: UniProtKB
Positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
Receptor clustering Source: GO_Central
Receptor localization to synapse Source: GO_Central
Regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl
Establishment of planar polarity Source: Ensembl
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Negative regulation of cell population proliferation Source: UniProtKB
Positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
Receptor clustering Source: GO_Central
Receptor localization to synapse Source: GO_Central
Regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl
Cellular Location
Cytosol; Extracellular space; AMPA glutamate receptor complex; Basolateral plasma membrane; Plasma membrane; Bicellular tight junction; Cell junction; Dendritic shaft; Glutamatergic synapse; Growth cone; Neuronal cell body; Postsynaptic density, intracellular component
Involvement in disease
Mental retardation, X-linked 90 (MRX90):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
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Anti-DLG3 antibodies
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Target: DLG3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBXS-5260
Application*: WB, IP, IF, E
Target: DLG3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Pig
Clone: CBXS-4891
Application*: WB, IP, IF, E, P
Target: DLG3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 2B6
Application*: E, WB
Target: DLG3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-3212
Application*: WB, IP
Target: DLG3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBXS-3211
Application*: WB, IP, IF, E
Target: DLG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 3F2
Application*: F, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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