Mouse Anti-DLG3 Recombinant Antibody (CBXS-3212) (CBMAB-CP2346-LY)

Name: Mouse Anti-DLG3 Recombinant Antibody (CBXS-3212)
SKU: CBMAB-CP2346-LY
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-DLG3 Recombinant Antibody (CBXS-3212) (CBMAB-CP2346-LY-1) in IP

Validation of spinophilin interactions. WT or spinophilin KO striatal (STR) or olfactory tubercle (OT) lysates were immunoprecipitated with a spinophilin antibody. Lysates or immunoprecipitates were immunoblotted for spinophilin and three interacting proteins that were detected in the HA immunoprecipitates that had a decreased (SAP102) or increased (Clathrin heavy chain and SRCIN1) interaction with spinophilin in amphetamine-treated animals. Spinophilin and all associated proteins were detected in the spinophilin immunoprecipitates from WT animals, but were absent in immunoprecipitates isolated from KO animals. ...View More

Watkins, D. S., True, J. D., Mosley, A. L., & Baucum, A. J. (2018). Proteomic analysis of the spinophilin interactome in rodent striatum following psychostimulant sensitization. Proteomes, 6(4), 53.

Datasheet

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Basic Information

Host Animal

Rabbit

Clone

CBXS-3212

Application

WB, IP

Immunogen

Synthetic peptide corresponding to residues near the C-terminus of human SAP102 protein.

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000
IP	1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA & Glycerol & HEPES

Preservative

Sodium Azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Discs Large MAGUK Scaffold Protein 3

Introduction

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Entrez Gene ID

Human	1741
Mouse	53310
Rat	58948

UniProt ID

Human	Q92796
Mouse	P70175
Rat	Q62936

Alternative Names

Discs Large MAGUK Scaffold Protein 3; Neuroendocrine-Dlg; Protein Phosphatase 1; Regulatory Subunit 82; Synapse-Associated Protein 102; SAP102; XLMR; Discs; Large Homolog 3 (Neuroendocrine-Dlg; Drosophila); Discs; Large Homolog 3 (Drosophila); Discs; Large Homolog 3;

Function

Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.

Biological Process

Cell-cell adhesion Source: GO_Central
Establishment of planar polarity Source: Ensembl
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Negative regulation of cell population proliferation Source: UniProtKB
Positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
Receptor clustering Source: GO_Central
Receptor localization to synapse Source: GO_Central
Regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl

Cellular Location

Cytosol; Extracellular space; AMPA glutamate receptor complex; Basolateral plasma membrane; Plasma membrane; Bicellular tight junction; Cell junction; Dendritic shaft; Glutamatergic synapse; Growth cone; Neuronal cell body; Postsynaptic density, intracellular component

Involvement in disease

Mental retardation, X-linked 90 (MRX90):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.

Sandestig, A., Green, A., Aronsson, J., Ellnebo, K., & Stefanova, M. (2019). A novel DLG3 mutation expanding the phenotype of X-linked intellectual disability caused by DLG3 Nonsense variants. Molecular Syndromology, 10(5), 281-285.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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