Mouse Anti-DLG3 Recombinant Antibody (3F2) (CBMAB-D1033-YC)

Name: Mouse Anti-DLG3 Recombinant Antibody (3F2)
SKU: CBMAB-D1033-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3F2

Application

FC, WB

Immunogen

A full length recombinant protein of human DLG3 produced in HEK293T cells.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:2,000
FC	1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA & Glycerol & PBS

Preservative

Sodium Azide

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Discs Large MAGUK Scaffold Protein 3

Introduction

DLG3 belongs to the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described.

Entrez Gene ID

Human	1741
Mouse	53310
Rat	58948

UniProt ID

Human	Q92796
Mouse	P70175
Rat	Q62936

Alternative Names

Discs Large MAGUK Scaffold Protein 3; Neuroendocrine-Dlg; Protein Phosphatase 1, Regulatory Subunit 82; Synapse-Associated Protein 102; SAP102; XLMR; Discs, Large Homolog 3 (Neuroendocrine-Dlg, Drosophila); Discs, Large Homolog 3 (Drosophila); Discs, Large Homolog 3;

Function

Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.

Biological Process

Cell-cell adhesion Source: GO_Central
Establishment of planar polarity Source: Ensembl
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Negative regulation of cell population proliferation Source: UniProtKB
Positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
Receptor clustering Source: GO_Central
Receptor localization to synapse Source: GO_Central
Regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl

Cellular Location

Cytosol; Extracellular space; AMPA glutamate receptor complex; Basolateral plasma membrane; Plasma membrane; Bicellular tight junction; Cell junction; Dendritic shaft; Glutamatergic synapse; Growth cone; Neuronal cell body; Postsynaptic density, intracellular component

Involvement in disease

Mental retardation, X-linked 90 (MRX90):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.

Sandestig, A., Green, A., Aronsson, J., Ellnebo, K., & Stefanova, M. (2019). A novel DLG3 mutation expanding the phenotype of X-linked intellectual disability caused by DLG3 Nonsense variants. Molecular Syndromology, 10(5), 281-285.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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