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Mouse Anti-DLG3 Recombinant Antibody (3F2) (CBMAB-D1033-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Discs Large MAGUK Scaffold Protein 3 (DLG3). The antibody can be used for immunoassay techniques, such as FC, WB.
See all DLG3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F2
Antibody Isotype
IgG1
Application
FC, WB

Basic Information

Immunogen
A full length recombinant protein of human DLG3 (NP_066943) produced in HEK293T cells
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Discs Large MAGUK Scaffold Protein 3
Introduction
DLG3 belongs to the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described.
Entrez Gene ID
1741
UniProt ID
Q92796
Alternative Names
Discs Large MAGUK Scaffold Protein 3; Neuroendocrine-Dlg; Protein Phosphatase 1, Regulatory Subunit 82; Synapse-Associated Protein 102; SAP102; XLMR; Discs, Large Homolog 3 (Neuroendocrine-Dlg, Drosophila); Discs, Large Homolog 3 (Drosophila); Discs, Large Homolog 3;
Function
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
Biological Process
Cell-cell adhesion Source: GO_Central
Establishment of planar polarity Source: Ensembl
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Negative regulation of cell population proliferation Source: UniProtKB
Positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
Receptor clustering Source: GO_Central
Receptor localization to synapse Source: GO_Central
Regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl
Cellular Location
Cytosol; Extracellular space; AMPA glutamate receptor complex; Basolateral plasma membrane; Plasma membrane; Bicellular tight junction; Cell junction; Dendritic shaft; Glutamatergic synapse; Growth cone; Neuronal cell body; Postsynaptic density, intracellular component
Involvement in disease
Mental retardation, X-linked 90 (MRX90):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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