DNAJC15

DNAJC15 (DnaJ Heat Shock Protein Family (Hsp40) Member C15) is a Protein Coding gene. Diseases associated with DNAJC15 include Cicatricial Entropion. An important paralog of this gene is DNAJC19.
Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member C15
Function
Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity).

Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.
Biological Process
Cellular response to starvation Source: Ensembl
Negative regulation of mitochondrial electron transport, NADH to ubiquinone Source: Ensembl
Negative regulation of protein-containing complex assembly Source: Ensembl
Protein import into mitochondrial matrix Source: GO_Central
Regulation of lipid metabolic process Source: Ensembl
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.
Topology
Mitochondrial intermembrane: 1-35
Helical: 36-58
Mitochondrial matrix: 59-150
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Anti-DNAJC15 antibodies

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Rabbit Anti-DNAJC15 Recombinant Antibody (CAP640) (CBMAB-AP1912LY)

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Target: DNAJC15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP640
Application*: IHC, WB
Datasheet SDS

Recombinant Rabbit Anti-DNAJC15 Antibody (CBAb085) (CBMAB-Ab085-LY)

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Target: DNAJC15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb085
Application*: WB, IH
Datasheet SDS

Rabbit Anti-DNAJC15 Recombinant Antibody (CAP640) (V2LY-0425-LY648)

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Target: DNAJC15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP640
Application*: IH, WB
Datasheet SDS

Rabbit Anti-DNAJC15 Recombinant Antibody (CBAb085) (V2LY-0425-LY647)

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Target: DNAJC15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb085
Application*: WB, P
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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