DNAJC15

DNAJC15 (DnaJ Heat Shock Protein Family (Hsp40) Member C15) is a Protein Coding gene. Diseases associated with DNAJC15 include Cicatricial Entropion. An important paralog of this gene is DNAJC19.

Full Name

DnaJ Heat Shock Protein Family (Hsp40) Member C15

Function

Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity).

Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.

Biological Process

Cellular response to starvation Source: Ensembl
Negative regulation of mitochondrial electron transport, NADH to ubiquinone Source: Ensembl
Negative regulation of protein-containing complex assembly Source: Ensembl
Protein import into mitochondrial matrix Source: GO_Central
Regulation of lipid metabolic process Source: Ensembl

Cellular Location

Mitochondrion inner membrane

Involvement in disease

Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.

Topology

Mitochondrial intermembrane: 1-35
Helical: 36-58
Mitochondrial matrix: 59-150

Anti-DNAJC15 antibodies

Rabbit Anti-DNAJC15 Recombinant Antibody (CAP640) (CBMAB-AP1912LY)

Datasheet

SDS

Target: DNAJC15

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CAP640

Application*: IHC, WB

Rabbit Anti-DNAJC15 Recombinant Antibody (CAP641) (CBMAB-AP1913LY)

Datasheet

SDS

Target: DNAJC15

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CAP641

Application*: IHC, WB

Recombinant Rabbit Anti-DNAJC15 Antibody (CBAb085) (CBMAB-Ab085-LY)

Datasheet

SDS

Target: DNAJC15

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBAb085

Application*: WB, IH

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)