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Recombinant Rabbit Anti-DNAJC15 Antibody (CBAb085) (CBMAB-Ab085-LY)

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Datasheet
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Basic Information

Host Animal
Rabbit
Clone
CBAb085
Application
WB 1:500-1:2000; IHC 1:50-1:200
Immunogen
Recombinant protein of human DNAJC15
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member C15
Entrez Gene ID
Human29103
Mouse66148
Rat290370
UniProt ID
HumanQ9Y5T4
MouseQ78YY6
RatD3ZCM4
Alternative Names
DNAJC15; DNAJD1; HSD18; MCJ; dnaJ homolog subfamily C member 15
Function
Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity).

Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.
Biological Process
Cellular response to starvation Source: Ensembl
Negative regulation of mitochondrial electron transport, NADH to ubiquinone Source: Ensembl
Negative regulation of protein-containing complex assembly Source: Ensembl
Protein import into mitochondrial matrix Source: GO_Central
Regulation of lipid metabolic process Source: Ensembl
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.
Topology
Mitochondrial intermembrane: 1-35
Helical: 36-58
Mitochondrial matrix: 59-150

Alessandrini, F., Pezzè, L., Menendez, D., Resnick, M. A., & Ciribilli, Y. (2018). ETV7-mediated DNAJC15 repression leads to doxorubicin resistance in breast cancer cells. Neoplasia, 20(8), 857-870.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rabbit Anti-DNAJC15 Recombinant Antibody (CBAb085) (CAT#: V2LY-0425-LY647)

Related Products

Rabbit Anti-DNAJC15 Recombinant Antibody (CBAb085) (CAT#: V2LY-0425-LY647)

Rabbit Anti-DNAJC15 Recombinant Antibody (CAP640) (CAT#: CBMAB-AP1912LY)

Rabbit Anti-DNAJC15 Recombinant Antibody (CAP640) (CAT#: V2LY-0425-LY648)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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