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Rabbit Anti-DNAJC15 Recombinant Antibody (CAP640) (CBMAB-AP1912LY)

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Datasheet
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Basic Information

Host Animal
Rabbit
Clone
CAP640
Application
IHC, WB
Immunogen
Recombinant protein of human DNAJC15
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member C15
Introduction
DNAJC15 (DnaJ Heat Shock Protein Family (Hsp40) Member C15) is a Protein Coding gene. Diseases associated with DNAJC15 include Cicatricial Entropion. An important paralog of this gene is DNAJC19.
Entrez Gene ID
Human29103
Mouse66148
Rat290370
UniProt ID
HumanQ9Y5T4
MouseQ78YY6
RatD3ZCM4
Alternative Names
DnaJ Heat Shock Protein Family (Hsp40) Member C15; DnaJ (Hsp40) Homolog, Subfamily C, Member 15; DnaJ (Hsp40) Homolog, Subfamily D, Member 1; Cell Growth-Inhibiting Gene 22 Protein; Methylation-Controlled J Protein; DNAJD1;
Function
Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity).

Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.
Biological Process
Cellular response to starvation Source: Ensembl
Negative regulation of mitochondrial electron transport, NADH to ubiquinone Source: Ensembl
Negative regulation of protein-containing complex assembly Source: Ensembl
Protein import into mitochondrial matrix Source: GO_Central
Regulation of lipid metabolic process Source: Ensembl
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.
Topology
Mitochondrial intermembrane: 1-35
Helical: 36-58
Mitochondrial matrix: 59-150

Alessandrini, F., Pezzè, L., Menendez, D., Resnick, M. A., & Ciribilli, Y. (2018). ETV7-mediated DNAJC15 repression leads to doxorubicin resistance in breast cancer cells. Neoplasia, 20(8), 857-870.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rabbit Anti-DNAJC15 Recombinant Antibody (CAP640) (CAT#: V2LY-0425-LY648)

Related Products

Recombinant Rabbit Anti-DNAJC15 Antibody (CBAb085) (CAT#: CBMAB-Ab085-LY)

Rabbit Anti-DNAJC15 Recombinant Antibody (CBAb085) (CAT#: V2LY-0425-LY647)

Rabbit Anti-DNAJC15 Recombinant Antibody (CAP640) (CAT#: V2LY-0425-LY648)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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