DOK3

DOK3 (Docking Protein 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include insulin receptor binding. An important paralog of this gene is DOK2.

Full Name

Docking Protein 3

Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).

Cellular Location

Cytoplasm; Cell membrane

PTM

Constitutively tyrosine-phosphorylated.
On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity).

Anti-DOK3 antibodies

Mouse Anti-DOK3 Recombinant Antibody (CBYCD-378) (CBMAB-D1506-YC)

Datasheet

SDS

Target: DOK3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYCD-378

Application*: WB

Rabbit Anti-DOK3 Recombinant Antibody (EG988) (CBMAB-EN1170-LY)

Datasheet

SDS

Target: DOK3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: EG988

Application*: WB: 1:500~1:1000 ELISA: 1:20000

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)