DOK3

DOK3 (Docking Protein 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include insulin receptor binding. An important paralog of this gene is DOK2.
Full Name
Docking Protein 3
Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
Cellular Location
Cytoplasm; Cell membrane
PTM
Constitutively tyrosine-phosphorylated.
On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity).
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Anti-DOK3 antibodies

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Mouse Anti-DOK3 Recombinant Antibody (EG988) (V2LY-0425-LY792)

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Target: DOK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: EG988
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DOK3 Recombinant Antibody (CBYCD-378) (V2LY-0425-LY791)

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Target: DOK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYCD-378
Application*: WB, IP, IF, E, P
Datasheet SDS

Rabbit Anti-DOK3 Recombinant Antibody (EG988) (CBMAB-EN1170-LY)

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Target: DOK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG988
Application*: WB: 1:500~1:1000 ELISA: 1:20000
Datasheet SDS

Mouse Anti-DOK3 Recombinant Antibody (CBYCD-378) (CBMAB-D1506-YC)

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Target: DOK3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYCD-378
Application*: WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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