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Rabbit Anti-DOK3 Recombinant Antibody (EG988) (CBMAB-EN1170-LY)

The product is antibody recognizes DOK3. The antibody EG988 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all DOK3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG988
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human DOK3.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Docking Protein 3
Introduction
DOK3 (Docking Protein 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include insulin receptor binding. An important paralog of this gene is DOK2.
Entrez Gene ID
Human79930
Mouse27261
UniProt ID
HumanQ7L591
MouseQ9QZK7
Alternative Names
Docking Protein 3; Downstream Of Tyrosine Kinase 3; Dok-Like Protein; DOKL;
Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
Cellular Location
Cytoplasm; Cell membrane
PTM
Constitutively tyrosine-phosphorylated.
On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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