Mouse Anti-DOK3 Recombinant Antibody (CBYCD-378) (CBMAB-D1506-YC)

Name: Mouse Anti-DOK3 Recombinant Antibody (CBYCD-378)
SKU: CBMAB-D1506-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCD-378

Application

Immunogen

E. coli-derived recombinant human DOK3, Gly181-Lys271, Accession # Q7L591

Specificity

Human

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Docking Protein 3

Introduction

DOK3 (Docking Protein 3) is a protein coding gene. Among its related pathways are Innate Immune System and B Cell Receptor Signaling Pathway (sino). It has proved that the protein has insulin receptor binding. And a paralog is DOK2.

Entrez Gene ID

79930

UniProt ID

Q7L591

Alternative Names

Docking Protein 3; Downstream Of Tyrosine Kinase 3; Dok-Like Protein; DOKL;

Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).

Cellular Location

Cytoplasm; Cell membrane

PTM

Constitutively tyrosine-phosphorylated.
On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity).

Zhang, Y., Zhang, S., Wang, Y., Yang, Z., Chen, Z., Wen, N., ... & Cai, L. (2021). ULK1 Suppresses Osteoclast Differentiation and Bone Resorption via Inhibiting Syk-JNK through DOK3. Oxidative medicine and cellular longevity, 2021.

Liu, X., Chen, F., & Li, W. (2020). Elevated expression of DOK3 indicates high suppressive immune cell infiltration and unfavorable prognosis of gliomas. International Immunopharmacology, 83, 106400.

Cai, X., Xing, J., Long, C. L., Peng, Q., & Humphrey, M. B. (2017). DOK3 modulates bone remodeling by negatively regulating osteoclastogenesis and positively regulating osteoblastogenesis. Journal of Bone and Mineral Research, 32(11), 2207-2218.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-DOK3 Recombinant Antibody (CBYCD-378) (CAT#: V2LY-0425-LY791)

Related Products

Mouse Anti-DOK3 Recombinant Antibody (EG988) (CAT#: V2LY-0425-LY792)

Rabbit Anti-DOK3 Recombinant Antibody (EG988) (CAT#: CBMAB-EN1170-LY)

Mouse Anti-DOK3 Recombinant Antibody (CBYCD-378) (CAT#: V2LY-0425-LY791)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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