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Mouse Anti-DOK3 Recombinant Antibody (CBYCD-378) (CBMAB-D1506-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Docking Protein 3 (DOK3). The antibody can be used for immunoassay techniques, such as WB.
See all DOK3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCD-378
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human DOK3, Gly181-Lys271, Accession # Q7L591
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Docking Protein 3
Introduction
DOK3 (Docking Protein 3) is a protein coding gene. Among its related pathways are Innate Immune System and B Cell Receptor Signaling Pathway (sino). It has proved that the protein has insulin receptor binding. And a paralog is DOK2.
Entrez Gene ID
79930
UniProt ID
Q7L591
Alternative Names
Docking Protein 3; Downstream Of Tyrosine Kinase 3; Dok-Like Protein; DOKL;
Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
Cellular Location
Cytoplasm; Cell membrane
PTM
Constitutively tyrosine-phosphorylated.
On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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