EIF4G3

The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p.
Full Name
eukaryotic translation initiation factor 4 gamma, 3
Research Area
Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.
Biological Process
Regulation of translational initiation Source: ProtInc
Cellular Location
Cytosol; Eukaryotic translation initiation factor 4F complex
PTM
Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
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Anti-EIF4G3 antibodies

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Mouse Anti-EIF4G3 Recombinant Antibody (1B4) (V2LY-0425-LY1780)

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Target: EIF4G3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1B4
Application*: WB, E
Datasheet SDS

Mouse Anti-EIF4G3 Recombinant Antibody (CBFYE-0742) (V2LY-0425-LY1779)

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Target: EIF4G3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYE-0742
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-EIF4G3 Recombinant Antibody (1B4) (CBMAB-A2548-LY)

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Target: EIF4G3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1B4
Application*: WB, E
Datasheet SDS

Mouse Anti-EIF4G3 Recombinant Antibody (CBFYE-0742) (CBMAB-E1175-FY)

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Target: EIF4G3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYE-0742
Application*: E, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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