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Mouse Anti-EIF4G3 Recombinant Antibody (CBFYE-0742) (CBMAB-E1175-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0742
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa1-515 from full-length human EIF4G3 with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
eukaryotic translation initiation factor 4 gamma, 3
Introduction
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p.
Entrez Gene ID
8672
UniProt ID
O43432
Alternative Names
Eukaryotic Translation Initiation Factor 4 Gamma 3; EIF-4-Gamma II; EIF-4-Gamma 3; EIF-4G 3; EIF4G 3; EIF4GII; Eukaryotic Translation Initiation Factor 4 Gamma, 3
Research Area
Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.
Biological Process
Regulation of translational initiation Source: ProtInc
Cellular Location
Cytosol; Eukaryotic translation initiation factor 4F complex
PTM
Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
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For research use only. Not intended for any clinical use.

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