Mouse Anti-EIF4G3 Recombinant Antibody (1B4) (CBMAB-A2548-LY)

The product is antibody recognizes EIF4G3. The antibody 1B4 immunoassay techniques such as: WB, ELISA.
See all EIF4G3 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1B4

Antibody Isotype

IgG2b, κ

Application

WB, ELISA

Basic Information

Immunogen

EIF4G3 (AAH30578, 1 a.a. ~ 515 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

eukaryotic translation initiation factor 4 gamma, 3

Entrez Gene ID

8672

UniProt ID

O43432

Alternative Names

eIF4GII

Research Area

Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.

Biological Process

Regulation of translational initiation Source: ProtInc

Cellular Location

Cytosol; Eukaryotic translation initiation factor 4F complex

PTM

Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.

References

Zang, X., Jiang, J., Gu, J., Chen, Y., Wang, M., Zhang, Y., ... & Zhang, X. (2022). Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of β-catenin by promoting δ-catenin ubiquitin degradation and upregulating SIK1. Molecular cancer, 21(1), 1-16.

Huang, X., Bi, N., Wang, J., Ren, H., Pan, D., Lu, X., & Wang, L. (2021). Chidamide and Radiotherapy Synergistically Induce Cell Apoptosis and Suppress Tumor Growth and Cancer Stemness by Regulating the MiR-375-EIF4G3 Axis in Lung Squamous Cell Carcinomas. Journal of Oncology, 2021.

Wang, Q., Wang, T., Hu, Y., Jiang, W., Lu, C., Zheng, W., ... & Cao, H. (2021). Corrigendum to" Circ-EIF4G3 promotes the development of gastric cancer by sponging miR-335"[Pathol.-Res. Pract. 215 (2019) 152507]. Pathology, research and practice, 217, 153163.

Wang, Q., Wang, T., Hu, Y., Jiang, W., Lu, C., Zheng, W., ... & Cao, H. (2019). Circ-EIF4G3 promotes the development of gastric cancer by sponging miR-335. Pathology-Research and Practice, 215(9), 152507.

Hu, J., Sun, F., & Handel, M. A. (2018). Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice. Biology of reproduction, 98(1), 102-114.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-EIF4G3 Recombinant Antibody (CBFYE-0742)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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