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ELANE

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.
Full Name
Elastase, Neutrophil Expressed
Research Area
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed:15140022).

Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984).
Biological Process
Acute inflammatory response to antigenic stimulus Source: GO_Central
Biosynthetic process of antibacterial peptides active against Gram-negative bacteria Source: UniProtKB
Cellular calcium ion homeostasis Source: UniProtKB
Defense response to bacterium Source: UniProtKB
Extracellular matrix disassembly Source: Reactome
Leukocyte migration involved in inflammatory response Source: Ensembl
Negative regulation of chemokine production Source: UniProtKB
Negative regulation of chemotaxis Source: UniProtKB
Negative regulation of inflammatory response Source: UniProtKB
Negative regulation of interleukin-8 production Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Neutrophil-mediated killing of fungus Source: Ensembl
Neutrophil-mediated killing of gram-negative bacterium Source: UniProtKB
Phagocytosis Source: GO_Central
Positive regulation of immune response Source: Ensembl
Positive regulation of interleukin-8 production Source: UniProtKB
Positive regulation of leukocyte tethering or rolling Source: Ensembl
Positive regulation of MAP kinase activity Source: UniProtKB
Positive regulation of smooth muscle cell proliferation Source: UniProtKB
Protein catabolic process Source: UniProtKB
Proteolysis Source: UniProtKB
Pyroptosis Source: Reactome
Response to lipopolysaccharide Source: Ensembl
Response to UV Source: UniProtKB
Response to yeast Source: Ensembl
Cellular Location
Phagosome. Localized in phagolysosomes following ingestion of E.coli by neutrophils.
Involvement in disease
Cyclic haematopoiesis (CH):
Autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.
Neutropenia, severe congenital 1, autosomal dominant (SCN1):
A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.

Anti-ELANE antibodies

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Target: ELANE
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP203
Application*: ELISA
Target: ELANE
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0142
Application*: E
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0140
Application*: P
Target: ELANE
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-0139
Application*: F, IC, P, WB
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0141
Application*: E, F, FN
Target: ELANE
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-0758
Application*: E, IF, P, WB
Target: ELANE
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYE-0757
Application*: E, IF, WB
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0756
Application*: E, WB
Target: ELANE
Host: Mouse
Antibody Isotype: IgG, κ
Specificity: Human
Clone: CBFYE-0136
Application*: F, IF
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0096
Application*: E, F
Target: ELANE
Host: Mouse
Specificity: Human
Clone: ELA10-101-5
Application*: E, N
Target: ELANE
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CELA3B/1811
Application*: WB, F, E, IF
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CELA3B/1757
Application*: WB, F, E, IF, P
Target: ELANE
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CELA3B/1374
Application*: F, E, IF
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M2110125
Application*: E
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 39A
Application*: E, F
Target: ELANE
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B11
Application*: SE, E
Target: ELANE
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-0871
Application*: P
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G7C2
Application*: E
Target: ELANE
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJN-0595
Application*: E
Target: ELANE
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-0594
Application*: E
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0593
Application*: E
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AHN-10
Application*: IF, IP, R
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0322
Application*: E, WB
Target: ELANE
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJN-0058
Application*: E, I
Target: ELANE
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBWJN-1087
Application*: WB
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1086
Application*: P
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0902
Application*: WB, F, IH, IC, MC
Target: ELANE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0901
Application*: WB, IH, F, IC, MC
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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