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EPOR

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Full Name
Erythropoietin Receptor
Research Area
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.

Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
Biological Process
Brain development Source: Ensembl
Decidualization Source: Ensembl
Heart development Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Cell membrane
Isoform EPOR-S: Secreted. Secreted and located to the cell surface.
Involvement in disease
Erythrocytosis, familial, 1 (ECYT1):
An autosomal dominant disorder characterized by elevated hemoglobin and hematocrit, hypersensitivity of erythroid progenitors to erythropoietin, erythropoietin low serum levels, and no increase in platelets nor leukocytes. It has a relatively benign course and does not progress to leukemia.
Topology
Extracellular: 25-250
Helical: 251-273
Cytoplasmic: 274-508
PTM
On EPO stimulation, phosphorylated on C-terminal tyrosine residues by JAK2. The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation. Phosphorylation on Tyr-454 is required for PTPN6 interaction, Tyr-426 for PTPN11. Tyr-426 is also required for SOCS3 binding, but Tyr-454/Tyr-456 motif is the preferred binding site.
Ubiquitination at Lys-281 mediates receptor internalization, whereas ubiquitination at Lys-453 promotes trafficking of activated receptors to the lysosomes for degradation (By similarity). Ubiquitinated by NOSIP; appears to be either multi-monoubiquitinated or polyubiquitinated. Ubiquitination mediates proliferation and survival of EPO-dependent cells.
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Anti-EPOR antibodies

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Mouse Anti-EPOR Recombinant Antibody (CBFYE-1073) (CBMAB-E1600-FY)

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Target: EPOR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-1073
Application*: WB, IH
Datasheet SDS

Rabbit Anti-EPOR (Phospho-Tyr368) Recombinant Antibody (EG1119) (V2LY-0825-LY552)

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Target: EPOR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG1119
Application*: E
Datasheet SDS

Mouse Anti-EPOR Recombinant Antibody (3D10) (V2LY-0825-LY551)

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Target: EPOR
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3D10
Application*: WB, E, IP
Datasheet SDS

Rabbit Anti-EPOR Recombinant Antibody (CBFYE-1075) (V2LY-0825-LY550)

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Target: EPOR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1075
Application*: E
Datasheet SDS

Mouse Anti-EPOR (Phospho-Tyr426) Recombinant Antibody (CBFYE-1071) (V2LY-0825-LY548)

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Target: EPOR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1071
Application*: WB
Datasheet SDS

Mouse Anti-EPOR Recombinant Antibody (CBFYE-1069) (V2LY-0825-LY547)

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Target: EPOR
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-1069
Application*: WB, F
Datasheet SDS

Mouse Anti-EPOR Recombinant Antibody (CBFYE-1068) (V2LY-0825-LY546)

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Target: EPOR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1068
Application*: B
Datasheet SDS

Mouse Anti-EPOR Recombinant Antibody (CBFYE-0244) (V2LY-0825-LY545)

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Target: EPOR
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-0244
Application*: IF
Datasheet SDS

Rabbit Anti-EPOR Recombinant Antibody (CBFYE-0095) (V2LY-0825-LY544)

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Target: EPOR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYE-0095
Application*: E
Datasheet SDS

Mouse Anti-EPOR Recombinant Antibody (E1603) (V2LY-0825-LY543)

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Target: EPOR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: E1603
Application*: E
Datasheet SDS

Mouse Anti-EPOR Recombinant Antibody (E1599) (V2LY-0825-LY542)

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Target: EPOR
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: E1599
Application*: E, WB, IP, IF
Datasheet SDS

EPOR Matched Antibody Pair (387) (APMAB-387LY)

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Target: EPOR
Specificity: Human
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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