FAF2

The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008]

Full Name

Fas Associated Factor Family Member 2

Research Area

Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460).

By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).

Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223).

Biological Process

Lipid droplet organization Source: MGI
Response to unfolded protein Source: UniProtKB-KW
Retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
Ubiquitin-dependent ERAD pathway Source: UniProtKB

Cellular Location

Endoplasmic reticulum; Cytoplasm; Lipid droplet