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Rabbit Anti-FAF2 Recombinant Antibody (CBCNC-599) (CBMAB-C3445-CN)

This product is a Rabbit antibody that recognizes FAF2. The antibody CBCNC-599 can be used for immunoassay techniques such as: WB, IP.
See all FAF2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBCNC-599
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Fas Associated Factor Family Member 2
Introduction
The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human23197
Mouse76577
Rat291000
UniProt ID
HumanQ96CS3
MouseQ3TDN2
RatQ5BK32
Alternative Names
Fas Associated Factor Family Member 2; UBX Domain-Containing Protein 3B; UBX Domain-Containing Protein 8; UBX Domain Containing 8; UBX Domain Protein 3B; UBXN3B; UBXD8;
Research Area
Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460).

By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).

Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223).
Biological Process
Lipid droplet organization Source: MGI
Response to unfolded protein Source: UniProtKB-KW
Retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
Ubiquitin-dependent ERAD pathway Source: UniProtKB
Cellular Location
Endoplasmic reticulum; Cytoplasm; Lipid droplet
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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